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Volume 23, Number 7—July 2017

Dispatch

Postmortem Findings for 7 Neonates with Congenital Zika Virus Infection

Anastácio Q. SousaComments to Author , Diane I.M. Cavalcante, Luciano M. Franco, Fernanda M.C. Araújo, Emília T. Sousa, José Telmo Valença-Junior, Dionne B. Rolim, Maria E.L. Melo, Pedro D.T. Sindeaux, Marialva T.F. Araújo, Richard D. Pearson, Mary E. Wilson, and Margarida M.L. Pompeu
Author affiliations: Federal University of Ceará, Fortaleza, Brazil (A.Q. Sousa, D.I.M. Cavalcante, L.M. Franco, E.T. Sousa, J.T. Valença-Junior, P.D.T. Sindeaux, M.M.L. Pompeu); Serviço de Verificação de Óbitos-SVO, Fortaleza (L.M. Franco, E.T. Sousa, J.T. Valença-Junior); Ceará State Central Public Health Laboratory, Fortaleza (F.M.C. Araújo, M.E.L. Melo); University of Fortaleza, Fortaleza (D.B. Rolim); Ceará State Secretariat of Health, Fortaleza (D.B. Rolim); Evandro Chagas Institute, Belém, Brazil (M.T.F. Araújo); University of Virginia School of Medicine, Charlottesville, Virginia, USA (R.D. Pearson); University of California, San Francisco, California, USA (M.E. Wilson); Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA (M.E. Wilson)

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Figure 1

Physical signs in 4 of 7 neonates who died of congenital Zika virus infection, Brazil. A) Neonate 1: typical microcephaly phenotype; arthrogryposis in upper and lower limbs. B) Neonate 7: microcephaly without the typical microcephaly phenotype; arthrogryposis is also present. C) Neonate 3: typical microcephaly phenotype, with head circumference within reference limits, frontal view. D) Neonate 3: typical microcephaly phenotype, with head circumference within reference limits, profile view. E) Br

Figure 1. Physical signs in 4 of 7 neonates who died of congenital Zika virus infection, Brazil. A) Neonate 1: typical microcephaly phenotype; arthrogryposis in upper and lower limbs. B) Neonate 7: microcephaly without the typical microcephaly phenotype; arthrogryposis is also present. C) Neonate 3: typical microcephaly phenotype, with head circumference within reference limits, frontal view. D) Neonate 3: typical microcephaly phenotype, with head circumference within reference limits, profile view. E) Brain of neonate 2: symmetric cerebellar hypoplasia (arrows) and vascular congestion. F) Brain of neonate 3: pachygyria and severe vascular congestion. G) Brain of neonate 3: ventriculomegaly and macroscopic calcifications (circles). H) Brain of neonate 7: cross-section showing ventriculomegaly.

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