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Volume 23, Number 7—July 2017

Dispatch

Postmortem Findings for 7 Neonates with Congenital Zika Virus Infection

Anastácio Q. SousaComments to Author , Diane I.M. Cavalcante, Luciano M. Franco, Fernanda M.C. Araújo, Emília T. Sousa, José Telmo Valença-Junior, Dionne B. Rolim, Maria E.L. Melo, Pedro D.T. Sindeaux, Marialva T.F. Araújo, Richard D. Pearson, Mary E. Wilson, and Margarida M.L. Pompeu
Author affiliations: Federal University of Ceará, Fortaleza, Brazil (A.Q. Sousa, D.I.M. Cavalcante, L.M. Franco, E.T. Sousa, J.T. Valença-Junior, P.D.T. Sindeaux, M.M.L. Pompeu); Serviço de Verificação de Óbitos-SVO, Fortaleza (L.M. Franco, E.T. Sousa, J.T. Valença-Junior); Ceará State Central Public Health Laboratory, Fortaleza (F.M.C. Araújo, M.E.L. Melo); University of Fortaleza, Fortaleza (D.B. Rolim); Ceará State Secretariat of Health, Fortaleza (D.B. Rolim); Evandro Chagas Institute, Belém, Brazil (M.T.F. Araújo); University of Virginia School of Medicine, Charlottesville, Virginia, USA (R.D. Pearson); University of California, San Francisco, California, USA (M.E. Wilson); Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA (M.E. Wilson)

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Figure 2

Histologic slides of tissues from 4 of 7 neonates who died of congenital Zika virus infection, Brazil. A) Neonate 1: severe cortical thinning (3 mm) with subventricular dystrophic calcification, reactive gliosis, and marked leptomeningeal congestion as well as marked depletion of neuronal precursors (original magnification ×10). B) Neonate 1: severe thinning of brain parenchyma (0.8 mm) with striking depletion of neuronal precursors (original magnification ×10). C) Neonate 1: lymphocytic leptome

Figure 2. Histologic slides of tissues from 4 of 7 neonates who died of congenital Zika virus infection, Brazil. A) Neonate 1: severe cortical thinning (3 mm) with subventricular dystrophic calcification, reactive gliosis, and marked leptomeningeal congestion as well as marked depletion of neuronal precursors (original magnification ×10). B) Neonate 1: severe thinning of brain parenchyma (0.8 mm) with striking depletion of neuronal precursors (original magnification ×10). C) Neonate 1: lymphocytic leptomeningitis (enlargement of box in panel B; original magnification ×20). D) Neonate 6: white matter with lymphocytic perivascular cuffing and severe gliosis (original magnification ×40). E) Neonate 3: marked parenchymal vascular congestion and scattered coarse dystrophic calcification (original magnification ×20). F) Neonate 3: finely granular intracellular calcification (original magnification ×40). G) Neonate 7: band-like pattern of coarse dystrophic calcification at the junction of gray and white matter (original magnification ×10). H) Neonate 6: red neurons (arrows) in brain parenchyma (original magnification ×40). I) Neonate 1: focal interstitial lymphocytic pulmonary infiltrate (original magnification ×40). J) Neonate 1: expansion of alveolar septa with scattered lymphocytic and macrophage infiltrate (original magnification ×40).

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