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Volume 23, Number 7—July 2017

Dispatch

Postmortem Findings for 7 Neonates with Congenital Zika Virus Infection

Anastácio Q. SousaComments to Author , Diane I.M. Cavalcante, Luciano M. Franco, Fernanda M.C. Araújo, Emília T. Sousa, José Telmo Valença-Junior, Dionne B. Rolim, Maria E.L. Melo, Pedro D.T. Sindeaux, Marialva T.F. Araújo, Richard D. Pearson, Mary E. Wilson, and Margarida M.L. Pompeu
Author affiliations: Federal University of Ceará, Fortaleza, Brazil (A.Q. Sousa, D.I.M. Cavalcante, L.M. Franco, E.T. Sousa, J.T. Valença-Junior, P.D.T. Sindeaux, M.M.L. Pompeu); Serviço de Verificação de Óbitos-SVO, Fortaleza (L.M. Franco, E.T. Sousa, J.T. Valença-Junior); Ceará State Central Public Health Laboratory, Fortaleza (F.M.C. Araújo, M.E.L. Melo); University of Fortaleza, Fortaleza (D.B. Rolim); Ceará State Secretariat of Health, Fortaleza (D.B. Rolim); Evandro Chagas Institute, Belém, Brazil (M.T.F. Araújo); University of Virginia School of Medicine, Charlottesville, Virginia, USA (R.D. Pearson); University of California, San Francisco, California, USA (M.E. Wilson); Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA (M.E. Wilson)

Main Article

Table

Results of tests for Zika virus in CSF and organs and for dengue virus in brain and CSF for 7 neonates who died of congenital Zika virus infection, Brazil*

Neonate no.
Zika virus rRT-PCR

DENV
CSF
Brain
Lung
Heart
Liver
Spleen
Kidney
Brain rRT-PCR
CSF
rRT-PCR
IgM†
NS1‡
1 P P P P N N P ND N N N
2 P P N P P P P ND ND N N
3 P P P P P P P ND ND N N
4 P P N N N N N N DENV-1 P P
5 P P P P P P P N N N N
6 P ND ND ND ND ND ND N N N N
7 P ND ND ND ND ND ND ND N N N

*CSF, cerebrospinal fluid; DENV, dengue virus; N, negative; ND, not done; NS1, nonstructural protein 1 (dengue virus antigen test); P, positive.
†By antigen capture assay.
‡By ELISA.

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