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Volume 23, Number 7—July 2017
Dispatch

Postmortem Findings for 7 Neonates with Congenital Zika Virus Infection

Anastácio Q. SousaComments to Author , Diane I.M. Cavalcante, Luciano M. Franco, Fernanda M.C. Araújo, Emília T. Sousa, José Telmo Valença-Junior, Dionne B. Rolim, Maria E.L. Melo, Pedro D.T. Sindeaux, Marialva T.F. Araújo, Richard D. Pearson, Mary E. Wilson, and Margarida M.L. Pompeu
Author affiliations: Federal University of Ceará, Fortaleza, Brazil (A.Q. Sousa, D.I.M. Cavalcante, L.M. Franco, E.T. Sousa, J.T. Valença-Junior, P.D.T. Sindeaux, M.M.L. Pompeu); Serviço de Verificação de Óbitos-SVO, Fortaleza (L.M. Franco, E.T. Sousa, J.T. Valença-Junior); Ceará State Central Public Health Laboratory, Fortaleza (F.M.C. Araújo, M.E.L. Melo); University of Fortaleza, Fortaleza (D.B. Rolim); Ceará State Secretariat of Health, Fortaleza (D.B. Rolim); Evandro Chagas Institute, Belém, Brazil (M.T.F. Araújo); University of Virginia School of Medicine, Charlottesville, Virginia, USA (R.D. Pearson); University of California, San Francisco, California, USA (M.E. Wilson); Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA (M.E. Wilson)

Main Article

Table

Results of tests for Zika virus in CSF and organs and for dengue virus in brain and CSF for 7 neonates who died of congenital Zika virus infection, Brazil*

Neonate no.
 Zika virus rRT-PCR
DENV
CSF
 Brain
 Lung
 Heart
 Liver
 Spleen
 Kidney
 Brain rRT-PCR
 CSF
rRT-PCR
 IgM†
 NS1‡
1 P P P P N N P ND N N N
2 P P N P P P P ND ND N N
3 P P P P P P P ND ND N N
4 P P N N N N N N DENV-1 P P
5 P P P P P P P N N N N
6 P ND ND ND ND ND ND N N N N
7 P ND ND ND ND ND ND ND N N N

*CSF, cerebrospinal fluid; DENV, dengue virus; N, negative; ND, not done; NS1, nonstructural protein 1 (dengue virus antigen test); P, positive.
†By antigen capture assay.
‡By ELISA.

Main Article

Page created: June 19, 2017
Page updated: June 19, 2017
Page reviewed: June 19, 2017
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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