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Volume 23, Number 8—August 2017


High Infection Rates for Adult Macaques after Intravaginal or Intrarectal Inoculation with Zika Virus

Andrew D. HaddowComments to Author , Aysegul Nalca, Franco D. Rossi, Lynn J. Miller, Michael R. Wiley, Unai Perez-Sautu, Samuel C. Washington, Sarah L. Norris, Suzanne E. Wollen-Roberts, Joshua D. Shamblin, Adrienne E. Kimmel, Holly A. Bloomfield, Stephanie M. Valdez, Thomas R. Sprague, Lucia M. Principe, Stephanie A. Bellanca, Stephanie S. Cinkovich, Luis Lugo-Roman, Lisa H. Cazares, William D. Pratt, Gustavo Palacios, Sina Bavari, M. Louise Pitt, and Farooq Nasar
Author affiliations: United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA

Main Article

Table 2

Serologic responses of 8 rhesus and cynomolgus macaques after intrarectal inoculation of Zika virus*

Macaque Sex Serologic response, PRNT80, by DPI
7 15 21 28
Rhesus 5 M 1:1,280 1:1,280 1:1,280
Rhesus 6 F 1:320 1:640 1:1,280
Rhesus 7 M 1:1,280 1:1,280 1:1,280
Rhesus 8 F 1:640 1:640 1:640
Cynomolgus 5 F 1:640 1:640 1:1,280
Cynomolgus 6 F 1:640 1:640 1:1,280
Cynomolgus 7 M 1:640 1:1,280 1:1,280
Cynomolgus 8 M 1:640 1:1280 1:1280

*Values are titers. Limit of detection was a titer of 1:20. DPI, day postinoculation; PRNT80, 80% plaque reduction neutralization test; –, no detectable serologic response.

Main Article