Volume 23, Number 8—August 2017
Research
High Infection Rates for Adult Macaques after Intravaginal or Intrarectal Inoculation with Zika Virus
Andrew D. Haddow
, Aysegul Nalca, Franco D. Rossi, Lynn J. Miller, Michael R. Wiley, Unai Perez-Sautu, Samuel C. Washington, Sarah L. Norris, Suzanne E. Wollen-Roberts, Joshua D. Shamblin, Adrienne E. Kimmel, Holly A. Bloomfield, Stephanie M. Valdez, Thomas R. Sprague, Lucia M. Principe, Stephanie A. Bellanca, Stephanie S. Cinkovich, Luis Lugo-Roman, Lisa H. Cazares, William D. Pratt, Gustavo Palacios, Sina Bavari, M. Louise Pitt, and Farooq Nasar
, Aysegul Nalca, Franco D. Rossi, Lynn J. Miller, Michael R. Wiley, Unai Perez-Sautu, Samuel C. Washington, Sarah L. Norris, Suzanne E. Wollen-Roberts, Joshua D. Shamblin, Adrienne E. Kimmel, Holly A. Bloomfield, Stephanie M. Valdez, Thomas R. Sprague, Lucia M. Principe, Stephanie A. Bellanca, Stephanie S. Cinkovich, Luis Lugo-Roman, Lisa H. Cazares, William D. Pratt, Gustavo Palacios, Sina Bavari, M. Louise Pitt, and Farooq Nasar
Table 2
Serologic responses of 8 rhesus and cynomolgus macaques after intrarectal inoculation of Zika virus*
| Macaque | Sex | Serologic response, PRNT80, by DPI |
|||
|---|---|---|---|---|---|
| 7 | 15 | 21 | 28 | ||
| Rhesus 5 | M | – | 1:1,280 | 1:1,280 | 1:1,280 |
| Rhesus 6 | F | – | 1:320 | 1:640 | 1:1,280 |
| Rhesus 7 | M | – | 1:1,280 | 1:1,280 | 1:1,280 |
| Rhesus 8 | F | – | 1:640 | 1:640 | 1:640 |
| Cynomolgus 5 | F | – | 1:640 | 1:640 | 1:1,280 |
| Cynomolgus 6 | F | – | 1:640 | 1:640 | 1:1,280 |
| Cynomolgus 7 | M | – | 1:640 | 1:1,280 | 1:1,280 |
| Cynomolgus 8 | M | – | 1:640 | 1:1280 | 1:1280 |
*Values are titers. Limit of detection was a titer of 1:20. DPI, day postinoculation; PRNT80, 80% plaque reduction neutralization test; –, no detectable serologic response.
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