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CDC EID journal Volume 23 Number 8—August 2017 Main Article

Volume 23, Number 8—August 2017

Research

High Infection Rates for Adult Macaques after Intravaginal or Intrarectal Inoculation with Zika Virus

Andrew D. HaddowComments to Author , Aysegul Nalca, Franco D. Rossi, Lynn J. Miller, Michael R. Wiley, Unai Perez-Sautu, Samuel C. Washington, Sarah L. Norris, Suzanne E. Wollen-Roberts, Joshua D. Shamblin, Adrienne E. Kimmel, Holly A. Bloomfield, Stephanie M. Valdez, Thomas R. Sprague, Lucia M. Principe, Stephanie A. Bellanca, Stephanie S. Cinkovich, Luis Lugo-Roman, Lisa H. Cazares, William D. Pratt, Gustavo Palacios, Sina Bavari, M. Louise Pitt, and Farooq Nasar
Author affiliations: United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA

Main Article

Table 2

Serologic responses of 8 rhesus and cynomolgus macaques after intrarectal inoculation of Zika virus*

Macaque Sex Serologic response, PRNT80, by DPI
7 15 21 28
Rhesus 5 M – 1:1,280 1:1,280 1:1,280
Rhesus 6 F – 1:320 1:640 1:1,280
Rhesus 7 M – 1:1,280 1:1,280 1:1,280
Rhesus 8 F – 1:640 1:640 1:640
Cynomolgus 5 F – 1:640 1:640 1:1,280
Cynomolgus 6 F – 1:640 1:640 1:1,280
Cynomolgus 7 M – 1:640 1:1,280 1:1,280
Cynomolgus 8 M – 1:640 1:1280 1:1280

*Values are titers. Limit of detection was a titer of 1:20. DPI, day postinoculation; PRNT80, 80% plaque reduction neutralization test; –, no detectable serologic response.

Main Article

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