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CDC EID journal Volume 23 Number 8—August 2017 Main Article

Volume 23, Number 8—August 2017

Research

High Infection Rates for Adult Macaques after Intravaginal or Intrarectal Inoculation with Zika Virus

Andrew D. HaddowComments to Author , Aysegul Nalca, Franco D. Rossi, Lynn J. Miller, Michael R. Wiley, Unai Perez-Sautu, Samuel C. Washington, Sarah L. Norris, Suzanne E. Wollen-Roberts, Joshua D. Shamblin, Adrienne E. Kimmel, Holly A. Bloomfield, Stephanie M. Valdez, Thomas R. Sprague, Lucia M. Principe, Stephanie A. Bellanca, Stephanie S. Cinkovich, Luis Lugo-Roman, Lisa H. Cazares, William D. Pratt, Gustavo Palacios, Sina Bavari, M. Louise Pitt, and Farooq Nasar
Author affiliations: United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA

Main Article

Table 1

Serologic responses of 8 female rhesus and cynomolgus macaques after intravaginal inoculation of Zika virus*

Macaque Serologic response, PRNT80, by DPI
7 15 21 28
Rhesus 1 – 1:640 1:640 1:640
Rhesus 2 – – – –
Rhesus 3 – – – –
Rhesus 4 – 1:640 1:640 1:640
Cynomolgus 1 – – – –
Cynomolgus 2 – – – –
Cynomolgus 3 – 1:640 1:640 1:640
Cynomolgus 4 – 1:1,280 1:1,280 1:1,280

*Values are titers. Limit of detection was a titer of 1:20. DPI, day postinoculation; PRNT80, 80% plaque reduction neutralization test; –, no detectable serologic response.

Main Article

The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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