Volume 23, Number 8—August 2017
Research
Human Infection with Highly Pathogenic Avian Influenza A(H7N9) Virus, China
Table
Key molecular signatures of avian influenza A(H7N9) virus from patient in Guangdong Province, China, compared with other closely related viruses*
Strain |
HA | NA | M2 | PB2 | PA | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
321–331† |
G186V‡ |
Q226L‡ |
R292K§ |
S31N¶ |
E627K# |
K526R** |
K702R†† |
V100A†† |
|||||
A/Guangdong/ 17SF006/2017 (H7N9)‡‡ | PEVPKRKRTAR/GL | V | Q | K | N | K | K | K | V | ||||
A/Guangdong/ 17SF003/2016 (H7N9) | PEVPKRKRTAR/GL | V | Q | K | N | E | K | R | V | ||||
A/Taiwan/1/2017 (H7N9) | PEVPKRKRTAR/GL | V | Q | K | N | K | R | K | A | ||||
A/Environment/ Guangdong/ C16283222/2016 (H7N9) | PEVPKGKRTAR/GL | V | Q | R | N | E | R | K | A | ||||
A/Fujian/3/2016 (H7N9) | PEIPKG—-R/GL | V | L | R | N | K | R | K | A | ||||
A/Zhejiang/3/2017 (H7N9) | PEIPKG—-R/GL | V | L | R | N | K | K | K | V | ||||
A/Netherlands/ 219/2003 (H7N7) | PEIPKRRRR/GL | G | Q | R | S | K | R | K | A |
*HA, hemagglutinin; NA, neuraminidase; NAI, neuraminidase inhibitor; M2, matrix protein 2; PA, polymerase acidic; PB2, polymerase basic 2.
†Cleavage site.
‡Receptor binding site.
§Associated with NAI drug resistance.
¶Associated with amantadine resistance.
#Associated with increased virulence in mice.
**Associated with enhanced viral replication in mammalian hosts.
††Species-associated signature position.
‡‡Virus from patient in this report.
1These authors contributed equally to this article.
2These authors contributed equally to this article.