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Volume 23, Number 8—August 2017

Research

Human Infection with Highly Pathogenic Avian Influenza A(H7N9) Virus, China

Changwen Ke1, Chris Ka Pun Mok1, Wenfei Zhu1, Haibo Zhou1, Jianfeng He, Wenda Guan, Jie Wu, Wenjun Song, Dayan Wang, Jiexiong Liu, Qinhan Lin, Daniel Ka Wing Chu, Lei Yang, Nanshan Zhong, Zifeng Yang2Comments to Author , Yuelong Shu2Comments to Author , and Joseph Sriyal Malik Peiris2
Author affiliations: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China (C. Ke, J. He, J. Wu); First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou (C.K.P. Mok, W. Guan, D.K.W. Chu, N. Zhong, Z. Yang, J.S.M. Peiris); The University of Hong Kong, Hong Kong, China (C.K.P. Mok, J.S.M. Peiris); National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China (W. Zhu, D. Wang, L. Yang, Y. Shu); The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan, China (H. Zhou, J. Liu, Q. Lin); Jinan University, Guangzhou (W. Song); Macau University of Science and Technology, Macau, China (N. Zhong, Z. Yang)

Main Article

Table

Key molecular signatures of avian influenza A(H7N9) virus from patient in Guangdong Province, China, compared with other closely related viruses*

Strain
 HA
NA
M2
PB2
PA
321–331†
 G186V‡
 Q226L‡
 R292K§
 S31N¶
 E627K#
 K526R**
 K702R††
 V100A††
A/Guangdong/ 17SF006/2017 (H7N9)‡‡ PEVPKRKRTAR/GL V Q K N K K K V
A/Guangdong/ 17SF003/2016 (H7N9) PEVPKRKRTAR/GL V Q K N E K R V
A/Taiwan/1/2017 (H7N9) PEVPKRKRTAR/GL V Q K N K R K A
A/Environment/ Guangdong/ C16283222/2016 (H7N9) PEVPKGKRTAR/GL V Q R N E R K A
A/Fujian/3/2016 (H7N9) PEIPKG—-R/GL V L R N K R K A
A/Zhejiang/3/2017 (H7N9) PEIPKG—-R/GL V L R N K K K V
A/Netherlands/ 219/2003 (H7N7) PEIPKRRRR/GL G Q R S K R K A

*HA, hemagglutinin; NA, neuraminidase; NAI, neuraminidase inhibitor; M2, matrix protein 2; PA, polymerase acidic; PB2, polymerase basic 2.
†Cleavage site.
‡Receptor binding site.
§Associated with NAI drug resistance.
¶Associated with amantadine resistance.
#Associated with increased virulence in mice.
**Associated with enhanced viral replication in mammalian hosts.
††Species-associated signature position.
‡‡Virus from patient in this report.

Main Article

1These authors contributed equally to this article.

2These authors contributed equally to this article.

Page created: July 18, 2017
Page updated: July 18, 2017
Page reviewed: July 18, 2017
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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