Volume 23, Number 9—September 2017
Similarities of Variant Creutzfeldt-Jakob Disease Strain in Mother and Son in Spain to UK Reference Case
|Characteristic||Patient 1||Patient 2||UK cases, n = 150|
|Case-patient age at illness onset, y||41||64||29 (mean)|
|Case-patient age at death, y||41||64||30 (mean)|
|Disease duration, mo||9||7||14 (mean)|
|Early visual symptoms||+||–||6%|
|No typical appearance of sporadic CJD on EEG†||+||+||100%|
|Bilateral symmetric pulvinar high signal on MRI scan of brain||Yes||Yes||93%|
|Positive tonsil biopsy result||ND||ND||19%|
|History of travel to or residence in United Kingdom||No||No||100%|
|Type 2B PrP||Yes||Yes||100%†|
*CJD, Creutzfeldt-Jakob disease; EEG, electroencephalogram; MRI, magnetic resonance imaging; PrP, prion protein; ND, not done; –, negative; +, positive.
†Of those tested.
1These senior authors contributed equally to this article.
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