Volume 23, Number 9—September 2017
Dispatch
Similarities of Variant Creutzfeldt-Jakob Disease Strain in Mother and Son in Spain to UK Reference Case
Table 2
Results of inoculation of brain tissue homogenates from 2 patients from Spain with vCJD and a reference patient from the United Kingdom into a panel of wild-type mice*
Brain inoculum source and mouse line | No. mice positive/no. total |
Incubation period, d, ± SEM (range) | |
---|---|---|---|
Clinical signs of prion disease | Vacuolar pathology | ||
UK reference case | |||
RIII | 10/15 | 10/15 | 395.3 ± 17.9 (295–489) |
C57BL/6 | 13/17 | 15/17 | 523.7 ± 19.7 (372–637) |
VM |
13/16 |
14/16 |
472.2 ± 16.1 387–552 |
Patient 1 | |||
RIII | 14/17 | 15/17 | 417 ± 14.2 (336–516) |
C57BL/6 | 12/18 | 12/18 | 588.4 ± 25.1 (405–706) |
VM |
7/18 |
11/18 |
472.2 ± 16.1 (387–552) |
Patient 2 | |||
RIII | 12/16 | 13/16 | 427.5 ± 18.4 (323–547) |
C57BL/6 | 9/18 | 11/18 | 604.9 ± 12.4 (567–692) |
VM | 4/16 | 7/16 | 524 ± 16.8 (501–573) |
*Bold indicates significant difference (p<0.05) when compared to the mouse line challenged with UK vCJD. vCJD, variant Creutzfeldt-Jakob disease.
1These senior authors contributed equally to this article.
Page created: August 17, 2017
Page updated: August 17, 2017
Page reviewed: August 17, 2017
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