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Volume 23, Number 9—September 2017

Dispatch

Similarities of Variant Creutzfeldt-Jakob Disease Strain in Mother and Son in Spain to UK Reference Case

Abigail B. DiackComments to Author , Aileen Boyle, Diane Ritchie, Chris Plinston, Dorothy Kisielewski, Jesús de Pedro-Cuesta, Alberto Rábano, Robert G. Will1, and Jean C. Manson1
Author affiliations: The Roslin Institute, Easter Bush, Scotland, UK (A.B. Diack, A. Boyle, C. Plinston, D. Kisielewski, J.C. Manson); University of Edinburgh, Edinburgh, Scotland, UK (D. Ritchie, R.G. Will); Carlos III Institute of Health, Madrid, Spain (J. de Pedro-Cuesta, A. Rábano)

Main Article

Table 2

Results of inoculation of brain tissue homogenates from 2 patients from Spain with vCJD and a reference patient from the United Kingdom into a panel of wild-type mice*

Brain inoculum source and mouse line No. mice positive/no. total
Incubation period, d, ± SEM (range)
Clinical signs of prion disease Vacuolar pathology
UK reference case
RIII 10/15 10/15 395.3 ± 17.9 (295–489)
C57BL/6 13/17 15/17 523.7 ± 19.7 (372–637)
VM
13/16
14/16
472.2 ± 16.1 387–552
Patient 1
RIII 14/17 15/17 417 ± 14.2 (336–516)
C57BL/6 12/18 12/18 588.4 ± 25.1 (405–706)
VM
7/18
11/18
472.2 ± 16.1 (387–552)
Patient 2
RIII 12/16 13/16 427.5 ± 18.4 (323–547)
C57BL/6 9/18 11/18 604.9 ± 12.4 (567–692)
VM 4/16 7/16 524 ± 16.8 (501–573)

*Bold indicates significant difference (p<0.05) when compared to the mouse line challenged with UK vCJD. vCJD, variant Creutzfeldt-Jakob disease.

Main Article

1These senior authors contributed equally to this article.

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