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Volume 24, Number 10—October 2018
Research

Molecular Evolution, Diversity, and Adaptation of Influenza A(H7N9) Viruses in China

Jing LuComments to Author , Jayna Raghwani1, Rhys Pryce, Thomas A. Bowden, Julien Thézé, Shanqian Huang, Yingchao Song, Lirong Zou, Lijun Liang, Ru Bai, Yi Jing, Pingping Zhou, Min Kang, Lina Yi, Jie Wu2, Oliver G. Pybus2, and Changwen Ke1Comments to Author 
Author affiliations: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China (J. Lu, Y. Song, L. Zou, L. Liang, R. Bai, Y. Jing, P. Zhou, M. Kang, L. Yi, J. Wu, C. Ke); Guangdong Provincial Institution of Public Health, Guangzhou (J. Lu, P. Zhou, L. Yi); University of Oxford, Oxford, UK (J. Raghwani, R. Pryce, T.A. Bowden, J. Thézé, O.G. Pybus); Beijing Normal University, Beijing, China (S. Huang)

Main Article

Figure 6

Structural analysis of amino acid changes in hemagglutinin in lineages B and C of influenza A(H7N9) viruses, China. Crystal structure of the homotrimeric H7 hemagglutinin bound to a human receptor analog (Protein Data Bank no. 4BSE) (27) (A) and rotated 90° counterclockwise (B) are shown. Two of the 3 protomers are displayed with high transparency to aid visualization. The carbon Cα positions of salient features are shown as spheres. Blue indicates receptor-binding residues, red indicates mutati

Figure 6. Structural analysis of amino acid changes in hemagglutinin in lineages B and C of influenza A(H7N9) viruses, China. Crystal structure of the homotrimeric H7 hemagglutinin bound to a human receptor analog (Protein Data Bank no. 4BSE) (27) (A) and rotated 90° counterclockwise (B) are shown. Two of the 3 protomers are displayed with high transparency to aid visualization. The carbon Cα positions of salient features are shown as spheres. Blue indicates receptor-binding residues, red indicates mutations in lineage B, green indicates mutations in lineage C, and orange indicates mutations in lineages B and C. Human receptor analog α2,6-SLN is shown as sticks colored according to constituent elements: carbon in orange, oxygen in red, and nitrogen in blue. Dark gray indicates the putative fusion peptide (32). Residues are numbered according to the H3 numbering system (Technical Appendix Table 2). A135 and L226 participate in receptor binding and thus are likely to modulate receptor specificity.

Main Article

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Main Article

1These authors contributed equally to this article.

2These senior authors jointly supervised this study.

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