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Volume 24, Number 11—November 2018
Research

Effects of Pneumococcal Conjugate Vaccine on Genotypic Penicillin Resistance and Serotype Changes, Japan, 2010–2017

Kimiko UbukataComments to Author , Misako Takata, Miyuki Morozumi, Naoko Chiba, Takeaki Wajima, Shigeo Hanada, Michi Shouji, Megumi Sakuma, Satoshi Iwata, and the Invasive Pneumococcal Diseases Surveillance Study Group
Author affiliations: Keio University School of Medicine, Tokyo, Japan (K. Ubukata, M. Takata, M. Morozumi, N. Chiba, M. Sakuma, S. Iwata); Tokyo University of Pharmacy and Life Sciences, Tokyo (T. Wajima); Toranomon Hospital, Tokyo (S. Hanada); National Cancer Center Hospital, Tokyo (M. Shouji, S. Iwata)

Main Article

Figure 2

Yearly changes in genotypic penicillin resistance in isolates from A) 1,006 children and B) 1,850 adults with invasive pneumococcal disease in Japan, April 2010–March 2017. Fiscal years extend from April 1 through March 31 of the following year. Genotypes based on abnormal pbp1a, pbp2x, and pbp2b genes were identified by real-time PCR and are represented as gPRSP (1a+2x+2b), gPISP (1a+2x), gPISP (1a+2b), gPISP (2x+2b), gPISP (2x), gPISP (2b), and gPSSP. g, genotype; PCV7, 7-valent pneumococcal c

Figure 2. Yearly changes in genotypic penicillin resistance in isolates from A) 1,006 children and B) 1,850 adults with invasive pneumococcal disease in Japan, April 2010–March 2017. Fiscal years extend from April 1 through March 31 of the following year. Genotypes based on abnormal pbp1a, pbp2x, and pbp2b genes were identified by real-time PCR and are represented as gPRSP (1a+2x+2b), gPISP (1a+2x), gPISP (1a+2b), gPISP (2x+2b), gPISP (2x), gPISP (2b), and gPSSP. g, genotype; PCV7, 7-valent pneumococcal conjugate vaccine; PCV13, 13-valent pneumococcal conjugate vaccine; PISP, penicillin-intermediate Streptococcus pneumoniae; PRSP, penicillin-resistant S. pneumoniae; PSSP, penicillin-susceptible S. pneumoniae.

Main Article

Page created: October 17, 2018
Page updated: October 17, 2018
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