Volume 24, Number 11—November 2018
Research
Effects of Pneumococcal Conjugate Vaccine on Genotypic Penicillin Resistance and Serotype Changes, Japan, 2010–2017
Table 3
Distribution of pneumococcal serotypes in adults before PCV7 and after introduction of PCV7 and PCV13 administration to children, Japan, April 2010–March 2017*
Serotype | No. (%) |
p value† | ||
---|---|---|---|---|
Pre-PCV7 period, 2010, n = 275 | PCV7 period, 2011–2013, n = 695 | PCV13 period, 2014–2016, n = 880 | ||
PCV7 | ||||
4 | 14 (5.1) | 27 (3.9) | 4 (0.5) | <0.001 |
6B | 42 (15.3) | 39 (5.6) | 22 (2.5) | <0.001 |
9V | 7 (2.5) | 7 (1.0) | 6 (0.7) | 0.042 |
14 | 21 (7.6) | 41 (5.9) | 6 (0.7) | <0.001 |
18C | 1 (0.4) | 3 (0.4) | 2 (0.2) | 0.642 |
19F | 14 (5.1) | 23 (3.3) | 15 (1.7) | 0.007 |
23F | 21 (7.6) | 28 (4.0) | 9 (1.0) | <0.001 |
Subtotal |
120 (43.6) |
168 (24.2) |
64 (7.3) |
<0.001 |
PCV13–nonPCV7‡ | ||||
1 | 1 (0.4) | 4 (0.6) | 13 (1.5) | 0.145 |
3 | 45 (16.4) | 110 (15.8) | 145 (16.5) | 0.939 |
5 | 0 | 1 (0.1) | 0 | NA |
6A | 11 (4.0) | 16 (2.3) | 9 (1.0) | 0.006 |
7F | 9 (3.3) | 9 (1.3) | 33 (3.8) | 0.006 |
19A | 18 (6.5) | 61 (8.8) | 99 (11.3) | 0.045 |
Subtotal |
84 (30.5) |
201 (28.9) |
299 (34.0) |
0.093 |
PPSV23–nonPCV13§ | ||||
8 | 0 | 2 (0.3) | 0 | NA |
10A | 10 (3.6) | 34 (4.9) | 54 (6.1) | 0.244 |
11A | 3 (1.1) | 23 (3.3) | 34 (3.9) | 0.058 |
12F | 5 (1.8) | 5 (0.7) | 63 (7.2) | <0.001 |
15B | 3 (1.1) | 14 (2.0) | 10 (1.1) | 0.356 |
20 | 1 (0.4) | 7 (1.0) | 14 (1.6) | 0.261 |
22F | 10 (3.6) | 63 (9.1) | 59 (6.7) | 0.008 |
33F | 2 (0.7) | 4 (0.6) | 11 (1.3) | 0.352 |
Subtotal |
34 (12.4) |
152 (21.9) |
245 (27.8) |
<0.001 |
NVT | ||||
6C | 13 (4.7) | 49 (7.1) | 52 (5.9) | 0.400 |
15A | 6 (2.2) | 28 (4.0) | 47 (5.3) | 0.068 |
15C | 0 | 12 (1.7) | 7 (0.8) | 0.034 |
23A | 2 (0.7) | 33 (4.7) | 50 (5.7) | <0.001 |
24F | 0 | 11 (1.6) | 16 (1.8) | 0.049 |
34 | 1 (0.4) | 5 (0.7) | 12 (1.4) | 0.301 |
35B | 7 (2.5) | 22 (3.2) | 55 (6.3) | 0.004 |
38 | 3 (1.1) | 7 (1.0) | 11 (1.3) | 0.955 |
Other¶ | 5 (1.8) | 6 (0.9) | 22 (2.5) | 0.042 |
Subtotal | 37 (13.5) | 173 (24.9)# | 272 (30.9) | <0.001 |
*Years run April 1– March 31 of the following year. NA, not applicable; NVT, nonvaccine serotype; PCV7, 7-valent pneumococcal conjugate vaccine; PCV13, 13-valent pneumococcal conjugate vaccine; PPSV23, 23-valent pneumococcal polysaccharide vaccine.
†p values compare the 3 surveillance periods; boldface indicates significant increase.
‡Serotypes added to PCV7.
§Serotypes contained in PPSV23 but not PCV13.
¶Includes 6D (n = 2), 7C (n = 8), 13 (n = 1), 16F (n = 6), 18B (n = 1), 23B (n = 5), 31 (n = 3), and 37 (n = 7).
#One strain identified as nontypeable was excluded from the table.