Volume 24, Number 11—November 2018
Research
Effects of Pneumococcal Conjugate Vaccine on Genotypic Penicillin Resistance and Serotype Changes, Japan, 2010–2017
Kimiko Ubukata
, Misako Takata, Miyuki Morozumi, Naoko Chiba, Takeaki Wajima, Shigeo Hanada, Michi Shouji, Megumi Sakuma, Satoshi Iwata, and the Invasive Pneumococcal Diseases Surveillance Study Group
, Misako Takata, Miyuki Morozumi, Naoko Chiba, Takeaki Wajima, Shigeo Hanada, Michi Shouji, Megumi Sakuma, Satoshi Iwata, and the Invasive Pneumococcal Diseases Surveillance Study Group
Table 2
Distribution of pneumococcal serotypes among children before PCV7 and after introduction of PCV7 and PCV13, Japan, April 2010–March 2017*
| Serotype | No. (%) |
p value† | ||
|---|---|---|---|---|
| Pre-PCV7 period, 2010, n = 300 | PCV7 period 2011–2013, n = 357 | PCV13 period, 2014–2016, n = 349 | ||
| PCV7 | ||||
| 4 | 7 (2.3) | 6 (1.7) | 0 | 0.007 |
| 6B | 83 (27.7) | 49 (13.7) | 2 (0.6) | <0.001 |
| 9V | 9 (3.0) | 2 (0.6) | 1 (0.3) | 0.005 |
| 14 | 34 (11.3) | 9 (2.5) | 0 | <0.001 |
| 18C | 4 (1.3) | 4 (1.1) | 1 (0.3) | 0.336 |
| 19F | 40 (13.3) | 13 (3.6) | 2 (0.6) | <0.001 |
| 23F | 43 (14.3) | 25 (7.0) | 2 (0.6) | <0.001 |
| Subtotal |
220 (73.3) |
108 (30.3) |
8 (2.3) |
<0.001 |
| PCV13–nonPCV7‡ | ||||
| 1 | 0 | 5 (1.4) | 13 (3.7) | <0.001 |
| 3 | 4 (1.3) | 7 (2.0) | 4 (1.1) | 0.724 |
| 5 | 0 | 0 | 0 | NA |
| 6A | 15 (5.0) | 6 (1.7) | 2 (0.6) | 0.001 |
| 7F | 1 (0.3) | 2 (0.6) | 6 (1.7) | 0.153 |
| 19A | 27 (9.0) | 58 (16.2) | 27 (7.7) | 0.001 |
| Subtotal |
47 (15.7) |
78 (21.8) |
52 (14.9) |
0.031 |
| PPSV23–nonPCV13§ | ||||
| 8 | 0 | 0 | 0 | NA |
| 10A | 2 (0.7) | 5 (1.4) | 18 (5.2) | <0.001 |
| 11A | 2 (0.7) | 1 (0.3) | 4 (1.1) | 0.356 |
| 12F | 1 (0.3) | 1 (0.3) | 33 (9.5) | <0.001 |
| 15B | 0 | 15 (4.2) | 26 (7.4) | <0.001 |
| 20 | 0 | 1 (0.3) | 0 | NA |
| 22F | 3 (1.0) | 16 (4.5) | 19 (5.4) | 0.003 |
| 33F | 1 (0.3) | 7 (2.0) | 17 (4.9) | 0.001 |
| Subtotal |
9 (3.0) |
46 (12.9) |
117 (33.5) |
<0.001 |
| NVT | ||||
| 6C | 9 (3.0) | 20 (5.6) | 11 (3.2) | 0.159 |
| 15A | 2 (0.7) | 25 (7.0) | 36 (10.3) | <0.001 |
| 15C | 1 (0.3) | 17 (4.8) | 16 (4.6) | <0.001 |
| 23A | 4 (1.3) | 13 (3.6) | 10 (2.9) | 0.176 |
| 24F | 1 (0.3) | 20 (5.6) | 52 (14.9) | <0.001 |
| 24B | 2 (0.7) | 4 (1.1) | 12 (3.4) | 0.197 |
| 34 | 1 (0.3) | 6 (1.7) | 7 (2.0) | 0.126 |
| 35B | 1 (0.3) | 10 (2.8) | 11 (3.2) | 0.016 |
| 38 | 1 (0.3) | 8 (2.2) | 7 (2.0) | 0.072 |
| Other¶ | 2 (0.7) | 2 (0.6) | 9 (2.6) | 0.041 |
| Subtotal | 24 (8.0) | 125 (35.0) | 171 (49.0)# | <0.001 |
*Years run from April 1 through March 31 of the following year. NA, not applicable; NVT, nonvaccine serotype; PCV7, 7-valent pneumococcal conjugate vaccine; PCV13, 13-valent pneumococcal conjugate vaccine; PPSV23, 23-valent pneumococcal polysaccharide vaccine.
†p values compare the 3 surveillance periods; boldface indicates significant increase..
‡Serotypes added to PCV7.
§Serotypes contained in PPSV23 but not PCV13.
¶Includes 7C (n = 2), 16F (n = 2), 21 (n = 2), 23B (n = 3), 28A (n = 1), 37 (n = 1), and 31 (n = 2).
#One strain identified as nontypeable was excluded from the table.
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Page updated: October 17, 2018
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