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Volume 24, Number 12—December 2018
Dispatch

In-Host Adaptation of Salmonella enterica Serotype Dublin during Prosthetic Hip Joint Infection

Faten El SayedComments to Author , Guillaume Sapriel, Nizar Fawal, Aurelia Gruber, Thomas Bauer, Beate Heym, Caroline Dupont, Henri-Jean Garchon, Jean-Louis Gaillard, Martin Rottman, and Simon Le HelloComments to Author 
Author affiliations: University of Versailles Saint-Quentin, Montigny-le-Bretonneux, France (F. El Sayed, G. Sapriel, B. Heym, H.-J. Garchon, J.-L. Gaillard); Hôpital Ambroise Paré, Boulogne-Billancourt, France (F. El Sayed, A. Gruber, T. Bauer, B. Heym, C. Dupont, J.-L. Gaillard, M. Rottman); Atelier de Bioinformatique, Paris, France (G. Sapriel); Institut Pasteur, Paris (N. Fawal, S. Le Hello); Hôpital Raymond Poincaré, Garches, France (M. Rottman)

Main Article

Table

Demographic characteristics of patients and sources for Salmonella enterica serotype Dublin and other Salmonella isolates, France, 2010–2016

Patient characteristic Salmonella Dublin, no (%) Other Salmonella, no. (%) p value*
All cases, N = 63,264
 642
 62,622
Sex†
F 266 30,762 <0.01
M
 363
 30,401
Age group, y‡
<1 4 (0.6) 3,767 (6.0) <0.01
1–5 33 (5.1) 15,302 (24.4) <0.01
6–14 19 (3.0) 8,636 (13.8) <0.01
15–64 199 (31.0) 23,653 (37.8) NS
>65 375 (58.4) 9,801 (15.7) <0.01
Unknown
 12 (1.9)
 1463 (2.3)
 NS
Type of human sample§¶
Feces 218 (34.0) 55,824 (89.1) <0.01
Blood 264 (41.1) 3,268 (5.2) <0.01
Urine 72 (11.2) 2,257 (3.6) <0.01
Articular 20 (3.1) 30 (0.05) <0.01
Pus 11 (1.7) 65 (0.1) <0.01
Bile 1 (0.2) 32 (<0.1) NS
Cerebrospinal fluid 0 23 (<0.1) NS
Other
 56 (8.7)
 1123 (1.8)
 <0.01
Hospitalization 368 (57.3) 20,556 (32.8) <0.01

*Pearson χ2 test used for statistical comparisons with significant difference if p<0.05. NS, nonsignificant.
†Numbers do not add to total because of patients for whom sex was unknown.
‡Median ages: Salmonella Dublin, 69.7 y (range <1–99); other Salmonella, 29.5 y (range <1–103); p<0.01.
§Ratio of blood to 1,000 fecal isolates: Salmonella Dublin, 1,211; other Salmonella, 58; p<0.01.
¶Prosthetic joint prevalence among patients: Salmonella Dublin, n = 10/642 (1.5%); other Salmonella, 11/62,622 (<0.1%); p<0.01.

Main Article

Page created: November 20, 2018
Page updated: November 20, 2018
Page reviewed: November 20, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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