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Volume 24, Number 2—February 2018

Research

Yersinia pestis Survival and Replication in Potential Ameba Reservoir

David W. MarkmanComments to Author , Michael F. Antolin, Richard A. Bowen, William H. Wheat, Michael Woods, Mercedes Gonzalez-Juarrero, and Mary Jackson
Author affiliations: Colorado State University, Fort Collins, Colorado, USA (D.W. Markman, M.F. Antolin, R.A. Bowen, W.H. Wheat, M. Gonzalez-Juarrero, M. Jackson); Burrell College of Osteopathic Medicine, Las Cruces, New Mexico, USA (M. Woods)

Main Article

Figure 5

Intraameba Yersinia pestis abundance in Dictyostelium discoideum across 2 postinfection antibiotic drug exposure periods, 1-hour and 4-hour. In D. discoideum, the abundance of viable intracellular Y. pestis was significantly greater at each successive time point (24 and 48 hours) after the 1-hour antibiotic drug treatment (p = 0.01 and p = 0.002, respectively). After the 4-hour antibiotic drug treatment in D. discoideum, the abundance of viable intracellular Y. pestis at 24 and 48 hours was sign

Figure 5. Intraameba Yersinia pestis abundance in Dictyostelium discoideum across 2 postinfection antibiotic drug exposure periods, 1 hour and 4 hour. In D. discoideum, the abundance of viable intracellular Y. pestis was significantly greater at each successive time point (24 and 48 hours) after the 1-hour antibiotic drug treatment (p = 0.01 and p = 0.002, respectively). After the 4-hour antibiotic drug treatment in D. discoideum, the abundance of viable intracellular Y. pestis at 24 and 48 hours was significantly greater than at 4 hours (p = 0.008 and p = 0.001, respectively). The abundance of viable Y. pestis within D. discoideum at 48 hours postinfection was not significantly different between the 1-hour and 4-hour antibiotic drug treatments (p = 0.1624). Viable intracellular Y. pestis abundance was significantly greater in D. discoideum compared with all other species at 48 hours postinfection (p<0.001).

Main Article

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