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Volume 24, Number 3—March 2018
Dispatch

Whole-Genome Analysis of Mycobacterium tuberculosis from Patients with Tuberculous Spondylitis, Russia

Ekaterina ChernyaevaComments to Author , Mikhail Rotkevich, Ksenia Krasheninnikova, Andrey Yurchenko, Anna Vyazovaya, Igor Mokrousov, Natalia Solovieva, Viacheslav Zhuravlev, Piotr Yablonsky, and Stephen J. O’Brien
Author affiliations: St. Petersburg State University, St. Petersburg, Russia (E. Chernyaeva, M. Rotkevich, K. Krasheninnikova, A. Yurchenko, P. Yablonsky, S.J. O’Brien); St. Petersburg Research Institute of Phthisiopulmonology, St. Petersburg (E. Chernyaeva, N. Solovieva, V. Zhuravlev, P. Yablonsky); University of Glasgow, Glasgow, Scotland, UK (A. Yurchenko); St. Petersburg Pasteur Institute, St. Petersburg (A. Vyazovaya, I. Mokrousov); Nova Southeastern University, Ft. Lauderdale, Florida, USA (S.J. O’Brien)

Main Article

Table

Mutations associated with drug resistance detected in Mycobacterium tuberculosis genomes

Tuberculosis drug
 Gene variant
 No. strains with confirmed drug resistance
 Drug-resistant strains, %
Isoniazid
 katG S315T 52 100
fabG-inhA-15 1
katG S315T 2
fabG-inhA-15
 2
Rifampin
 rpoB S450L 40 100
rpoB D435V 2
rpoB H445D 1
rpoB H445R 1
rpoB D574E
 1
Streptomycin
 rpsL K43R 33 96.4
rpsL K88R 5
gid G48G 1
gid G34G 1
rrs516
 12
Ofloxacin
 gyrA D94N 1 81.8
gyrA D94Y 1
gyrA D94G 5
gyrA D94A
 2
Ethambutol
 embA-16 4 72.7
embA-8 1
embB M3061 2
embB S3471 1
embB N399T 1
embB G406D 2
embB G406A 2
embB A453A 1
embB Q497R
 2
Pyrazinamide
 rpsA D123A 1 55.6
rpsA A412V 1
pncA L159R 1
pncA C138R 1
pncA T135P 1
pncA V130E 1
pncA Q122Stop 1
pncA Y103Stop 2
pncA G97S
 1
Kanamycin eis-37 4 55.0
eis-14 3
eis-10 4

Main Article

Page created: February 16, 2018
Page updated: February 16, 2018
Page reviewed: February 16, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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