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Volume 24, Number 3—March 2018
Research

Major Threat to Malaria Control Programs by Plasmodium falciparum Lacking Histidine-Rich Protein 2, Eritrea

Araia Berhane, Karen F. Anderson, Selam Mihreteab, Karryn Gresty, Eric Rogier, Salih Mohamed, Filmon Hagos, Ghirmay Embaye, Anderson Chinorumba, Assefash Zehaie, Simone Dowd, Norman C. Waters, Michelle L. Gatton, Venkatachalam Udhayakumar, Qin ChengComments to Author , and Jane Cunningham
Author affiliations: Ministry of Health, Asmara, Eritrea (A. Berhane, S. Mihreteab, S. Mohamed, F. Hagos, G. Embaye); Australian Defence Force Malaria and Infectious Disease Institute, Brisbane, Queensland, Australia (K. Anderson, K. Gresty, S. Dowd, Q. Cheng); QIMR–Berghofer Medical Research Institute, Brisbane (K. Anderson, K. Gresty, S. Dowd, Q. Cheng); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (E. Rogier, V. Udhayakumar); World Health Organization, Geneva, Switzerland (A. Chinorumba, J. Cunningham); World Health Organization, Asmara (A. Zehaie); Walter Reed Army Institute of Research, Silver Spring, Maryland, USA (N.C. Waters); Queensland University of Technology, Brisbane (M.L. Gatton)

Main Article

Table 2

Frequency of pfhrp2, pfhrp3, and flanking genes in patients infected with Plasmodium falciparum at 2 hospitals, Eritrea*

Hospital Upstream pfhrp2 Downstream No. (%) Upstream pfhrp3 Downstream No. (%)
Ghindae + + + 4 (15.4) + + + 2 (7.7)
+ – – 2 (7.7)
– + + 1 (3.9) – – – 1 (3.9)
– – + 21 (80.8) – – – 21 (80.8)
Subtotal 26 26
Massawa + + + 7 (29.2) + + + 6 (25.0)
+ – – 1 (4.2)
– + + 7 (29.2) + + + 1 (4.2)
+ – – 6 (25.0)
– – + 10 (41.7) – – + 2 (8.3)
– – – 8 (33.3)
Subtotal 24 24
Combined + + + 11 (22.0) + + + 8 (16.0)
+ – – 3 (6.0)
– + + 8 (16.0) + + + 1 (2.0)
+ – – 6 (12.0)
– – – 1 (2.0)
– – + 31 (62.0) – – + 2 (4.0)
– – – 29 (58.0)
Total 50 50

*Parasites with same presence or absence pattern for pfhrp2 and flanking genes but different presence or absence pattern for pfhrp3 and flanking genes are separated into subgroups. pfhrp, P. falciparum histidine-rich protein +, positive; –, negative.

Main Article

Page created: February 15, 2018
Page updated: February 15, 2018
Page reviewed: February 15, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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