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Volume 24, Number 4—April 2018
Dispatch

Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans

Seiya Yamayoshi1, Maki Kiso, Atsuhiro Yasuhara, Mutsumi Ito, Yuelong Shu, and Yoshihiro Kawaoka1Comments to Author 
Author affiliations: University of Tokyo, Tokyo, Japan (S. Yamayoshi, M. Kiso, A. Yasuhara, M. Ito, Y. Kawaoka); Sun Yat-Sen University, Shenzhen, China (Y. Shu); Chinese Centers for Disease Control and Prevention, Beijing, China (Y. Shu); University of Wisconsin–Madison, Madison, Wisconsin, USA, and Japan Science and Technology Agency, Saitama, Japan (Y. Kawaoka)

Main Article

Table 2

Titers of influenza A(H7N9) GD virus in organs of experimentally infected mice*

Virus
 Postinfection day 3, mean log10 PFU ± SD/g
Postinfection day 6, mean log10 PFU ± SD/g
Lung
 NT
 Brain
 Lung
 NT
 Brain
GD wild-type 5.7 ± 0.2 4.2 ± 0.8 ND 5.8 ± 0.4 5.9 ± 0.7 3.2
GD/PB2-482K ND, p<0.01 ND, p<0.01 ND 3.0, 3.4, p<0.01 2.6 ± 0.4, p<0.05 ND
GD/PB2-588A 3.3 ± 0.6, p<0.01 3.1, p<0.01 ND 4.6 ± 0.8 4.4 ± 2.5 ND
GD/PB2-482K-588A ND, p<0.01 ND, p<0.01 ND 3.1 ± 0.3, p<0.05 ND, p<0.01 ND
GD/PA-497K 5.1 ± 0.2, p<0.05 2.9 ± 1.0 ND 4.6 ± 1.0 5.8 ± 0.4 ND
GD/PB2-482K-588A+PA-497K ND, p<0.01 ND, p<0.01 ND 2.2, 2.7, p<0.01 ND, p<0.01 ND

*BALB/c mice were intranasally inoculated with 102 PFU of virus (in 50 μL). Three animals per group were euthanized on postinfection days 3 and 6. Statistically significant differences compared with GD wild-type–infected mice were determined by use of a 1-way analysis of variance followed by a Dunnett test. GD, A/Guangdong/17SF003/2016; ND, virus not detected (detection limit ≈2 log10 PFU/g); NT, nasal turbinates; PA, polymerase acidic; PB, polymerase basic.

Main Article

1These senior authors contributed equally to this article.

Page created: March 19, 2018
Page updated: March 19, 2018
Page reviewed: March 19, 2018
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