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Volume 24, Number 4—April 2018
Dispatch

Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans

Seiya Yamayoshi1, Maki Kiso, Atsuhiro Yasuhara, Mutsumi Ito, Yuelong Shu, and Yoshihiro Kawaoka1Comments to Author 
Author affiliations: University of Tokyo, Tokyo, Japan (S. Yamayoshi, M. Kiso, A. Yasuhara, M. Ito, Y. Kawaoka); Sun Yat-Sen University, Shenzhen, China (Y. Shu); Chinese Centers for Disease Control and Prevention, Beijing, China (Y. Shu); University of Wisconsin–Madison, Madison, Wisconsin, USA, and Japan Science and Technology Agency, Saitama, Japan (Y. Kawaoka)

Main Article

Table 1

Amino acid differences between PB2 and PA in 2 influenza A(H7N9) viruses*

Virus
 PB2
PA
191
 340
 482
 559
 560
 584
 588
 702
 100
 262
 387
 394
 465
 497
GD wild-type E K R T I I V R V K I D V R
AN/PB2-627E† K R K N V V A K A R V N I K

*AN, A/Anhui/1/2013(H7N9); GD, A/Guangdong/17SF003/2016; PA, polymerase acidic; PB, polymerase basic.
†This mutant possessed a K to E substitution at position 627 of PB2, but the other residues of PB2 and PA were identical to those of wild-type AN.

Main Article

1These senior authors contributed equally to this article.

Page created: March 19, 2018
Page updated: March 19, 2018
Page reviewed: March 19, 2018
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