Volume 24, Number 4—April 2018
Dispatch
Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans
Figure 1

Figure 1. Viral polymerase activity of wild-type, PB2 mutant, and PA mutant polymerase complexes. A) Viral polymerase activities of highly pathogenic influenza A(H7N9) virus GD replication complexes harboring amino acid substitutions in PB2 (A), PA (B), or PB2 and PA (C) in human A549 and chicken DF-1 cells. The data shown are relative polymerase activities ± SD (n = 3). The polymerase activity of GD wild-type was set to 100%. **p<0.01, according to a 1-way analysis of variance followed by a Dunnett test. Error bars indicate SD. AN, A/Anhui/1/2013(H7N9); GD, A/Guangdong/17SF003/2016; PA, polymerase acidic; PB, polymerase basic.
1These senior authors contributed equally to this article.