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Volume 24, Number 4—April 2018
Dispatch

mcr-1 in Carbapenemase-Producing Klebsiella pneumoniae with Hospitalized Patients, Portugal, 2016–2017

Ana Constança Mendes1, Ângela Novais1, Joana Campos, Carla Rodrigues, Cláudia Santos, Patrícia Antunes, Helena Ramos, and Luísa PeixeComments to Author 
Author affiliations: Centro Hospitalar do Porto, Porto, Portugal (A.C. Mendes, C. Santos, H. Ramos); Faculdade de Farmácia, Universidade do Porto, Porto (Â. Novais, J. Campos, C. Rodrigues, P. Antunes, L. Peixe); Faculdade de Ciências da Nutrição e Alimentação, Universidade do Porto, Porto (P. Antunes)

Main Article

Table

Demographic and epidemiologic data for 16 patients with Klebsiella pneumoniae isolates producing KPC-3 and MCR-1, Porto, Portugal, 2016–2017*

Patient no. Patient age, y/sex MLST Date of isolation Unit Specimen type Antimicrobial drug resistance profile of non-β-lactams†
1 50/M ST45 2016 Sep 10 ICU-B Rectal swab GEN, KAN, NET, TOB, STR, TET, MIN, TGC, FOT, TMP, SXT, NAL, CIP
ST45 2016 Sep 23 TU Peritoneal fluid GEN, KAN, NET, TOB, STR, TET, MIN, TGC, FOT, TMP, SXT, CAM, NAL, CIP
ST45 2016 Oct 14 ICU-B Rectal swab MIN, FOT, TET, TGC, SXT, CAM, NAL, CIP
ST45
 2016 Nov 8
 TU
 Urine
 GEN, KAN, NET, TOB, STR, TET, MIN, TGC, FOT, TMP, SXT, NAL, CIP
2
 55/M
 ST45
 2016 Sep 11
 TU
 Rectal swab
 GEN, NET, TOB, STR, TET, MIN, TGC, FOT, TMP, SXT, CAM, NAL, CIP
3
 58/F
 ST45
 2016 Sep 12
 ICU-A
 Rectal swab
 GEN, KAN, NET, TOB, STR, TET, MIN, TGC, FOT, TMP, SXT, CAM, NAL, CIP
4 73/F ST45 2016 Oct 1 MED-B Rectal swab GEN, KAN, NET, TOB, STR, TET, MIN, TGC, FOT, TMP, SXT, CAM, NAL, CIP
ST45 2016 Oct 4 MED-A Urine GEN, KAN, NET, TOB, STR, TET, MIN, TGC, FOT, TMP, SXT, NAL, CIP
ST1112
 2016 Oct 22
 ICU-B
 Pus
 TET, MIN, FOT, TMP, CAM, NAL, CIP
5 72/M ST45 2016 Oct 10 ICU-A Rectal swab GEN, KAN, NET, TOB, TET, MIN, TGC, FOT, CAM, NAL, CIP
ST45‡
 2016 Oct 14
 ICU-A
 Rectal swab
 GEN, KAN, NET, TOB, TET, MIN, TGC, FOT, CAM, NAL, CIP
6
 75/M
 ST45
 2016 Oct 14
 ICU-A
 Rectal swab
 GEN, KAN, NET, TOB, STR, TET, MIN, TGC, FOT, TMP, SXT, CAM, NAL, CIP
7
 68/M
 ST45
 2016 Oct 14
 SURG
 Rectal swab
 GEN, KAN, TOB, STR, TET, MIN, TGC, FOT, TMP, SXT, NAL, CIP
8
 78/F
 ST45
 2016 Oct 15
 ICU-A
 Rectal swab
 GEN, KAN, NET, TOB, STR, TET, MIN, TGC, FOT, TMP, SXT, CAM, NAL, CIP
9
 58/M
 ST45
 2016 Oct 25
 TU
 Rectal swab
 GEN, KAN, NET, TOB, STR, TET, MIN, TGC, FOT, TMP, SXT, CAM, NAL, CIP
10
 51/M
 ST45
 2016 Nov 1
 MED-C
 Rectal swab
 KAN, NET, TOB, STR, TET, MIN, TGC, TMP, SXT, CAM, NAL, CIP
11
 87/F
 ST45‡
 2016 Nov 1
 ICU-B
 Rectal swab
 GEN, KAN, STR, TET, MIN, TGC, FOT, TMP, SXT, NAL, CIP
12
 67/F
 ST45
 2016 Nov 7
 ICU-A
 Rectal swab
 GEN, TOB, STR, MIN, TGC, FOT, CAM, NAL, CIP
13
 57/M
 ST45
 2016 Nov 7
 ICU-B
 Blood
 GEN, NET, TOB, STR, TET, MIN, TGC, FOT, CAM, NAL
14 76/M ST45 2016 Dec 30 MED-B Blood GEN, KAN, NET, TOB, STR, TET, MIN, TGC, FOT, TMP, SXT, CAM, NAL, CIP
ST45
 2017 Jan 2
 MED-B
 Rectal swab
 GEN, KAN, NET, TOB, STR, TET, MIN, TGC, TMP, SXT, NAL, CIP
15 85/F ST45 2017 Jan 16 MED-A Rectal swab GEN, KAN, NET, TOB, STR, TET, MIN, TGC, FOT, TMP, SXT, CAM, NAL, CIP
ST45
 2017 Feb 7
 MED-A
 Urine
 GEN, NET, TOB, STR, TGC, TMP, SXT, NAL, CIP
16 63/F ST45 2017 Feb 7 ICU-B Rectal swab GEN, KAN, NET, TOB, STR, TET, MIN, TGC, TMP, SXT, NAL, CIP

*CAM, chloramphenicol; CIP, ciprofloxacin; FOT, fosfomycin; GEN, gentamicin; ICU, intensive care unit; KAN, kanamycin; KPC-3, K. pneumoniae carbapenemase 3; MCR-1, mobilized colistin resistance 1; MED, medical unit; MIN, minocycline; MLST, multilocus sequence type; NAL, nalidixic acid; NET, netilmicin; SURG, surgical unit; ST, sequence type; STR, streptomycin; SXT, trimethoprim/sulfamethoxazole; TET, tetracycline; TGC, tigecycline; TOB, tobramycin; TMP, trimethoprim; TU, transplant unit.
†We considered isolates with intermediate susceptibility profiles resistant.
‡Isolates selected for whole-genome sequencing.

Main Article

1These authors contributed equally to this article.

Page created: March 19, 2018
Page updated: March 19, 2018
Page reviewed: March 19, 2018
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