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Volume 24, Number 6—June 2018
Research

Genomic Epidemiology of Global Carbapenemase-Producing Enterobacter spp., 2008–2014

Gisele Peirano1, Yasufumi Matsumura1, Mark D. Adams2, Patricia Bradford, Mary Motyl, Liang Chen, Barry N. Kreiswirth, and Johann D.D. PitoutComments to Author 
Author affiliations: University of Calgary, Calgary, Alberta, Canada (G. Peirano, J.D.D. Pitout); Kyoto University Graduate School of Medicine, Kyoto, Japan (Y. Matsumura); J. Craig Venter Institute, La Jolla, California, USA (M.D. Adams); AstraZeneca Pharmaceuticals LP, Waltham, Massachusetts, USA (P. Bradford); Merck & Co., Inc., Rahway, New Jersey, USA (M. Motyl); Rutgers University, Newark, New Jersey, USA (L. Chen, B.N. Kreiswirth); University of Pretoria, Pretoria, South Africa (J.D.D. Pitout)

Main Article

Figure 3

Phylogenetic tree of the different clades among 51 Enterobacter hormaechei subsp. steigerwaltii ST90 and ST93 isolates identified from Enterobacter spp. isolates collected in the Merck Study for Monitoring Antimicrobial Resistance Trends, 2008–2014, and the AstraZeneca global surveillance program, 2012–2014. The tree is rooted with E. hormaechei subsp. hormaechei isolate ATCC49162. A total of 317,867 core single-nucleotide polymorphisms were found; 27,705 were used to draw the tree (after phage

Figure 3. Phylogenetic tree of the different clades among 51 Enterobacter hormaechei subsp. steigerwaltii ST90 and ST93 isolates identified from Enterobacter spp. isolates collected in the Merck Study for Monitoring Antimicrobial Resistance Trends, 2008–2014, and the AstraZeneca global surveillance program, 2012–2014. The tree is rooted with E. hormaechei subsp. hormaechei isolate ATCC49162. A total of 317,867 core single-nucleotide polymorphisms were found; 27,705 were used to draw the tree (after phages and recombination sites were excluded). The isolates from other studies were negative for carbapenemases. Clades are grouped by color. KPC, Klebsiella pneumoniae carbapenemase; NDM, New Delhi metallo-β-lactamase; OXA, oxacillin; ST, sequence type; –, information missing. Scale bar indicates nucleotide substitutions per site.

Main Article

1These co-authors contributed equally to this article.

2Current affiliation: Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA.

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Page updated: May 17, 2018
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