Occupation-Associated Fatal Limbic Encephalitis Caused by Variegated Squirrel Bornavirus 1, Germany, 2013
, Kore Schlottau, Daniel Cadar, Bernd Hoffmann, Lorenz Balke, Burkhard Bewig, Donata Hoffmann, Philip Eisermann, Helmut Fickenscher, Andi Krumbholz, Helmut Laufs, Monika Huhndorf, Maria Rosenthal, Walter Schulz-Schaeffer, Gabriele Ismer, Sven-Kevin Hotop, Mark Brönstrup, Anthonina Ott, Jonas Schmidt-Chanasit1
, and Martin Beer1
Author affiliations: Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany (D. Tappe, D. Cadar, P. Eisermann, M. Rosenthal, J. Schmidt-Chanasit); Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany (K. Schlottau, B. Hoffmann, D. Hoffmann, M. Beer); University Medical Center Schleswig-Holstein, Kiel, Germany (L. Balke, B. Bewig, H. Laufs, M. Huhndorf); Christian-Albrecht University of Kiel and University Medical Center, Kiel (H. Fickenscher, A. Krumbholz); Saarland University Medical Center, Homburg, Germany (W. Schulz-Schaeffer); Zoological Garden, Schleswig-Holstein, Germany (G. Ismer); Helmholtz Centre for Infection Research and German Centre for Infection Research, Braunschweig, Germany (S.-K. Hotop, M. Brönstrup); Euroimmun AG, Lübeck, Germany (A. Ott); German Centre for Infection Research, Hamburg (J. Schmidt-Chanasit)
Figure 2. Phylogenetic analysis of complete coding sequences from variegated squirrel bornavirus 1 (VSBV-1) and other members of Bornaviridae. The phylogenetic trees were inferred by using the Bayesian Markov Chain Monte Carlo method and in parallel a maximum-likelihood method (tree not shown). Statistical support of grouping from Bayesian posterior probabilities (clade credibilities >90%) and maximum-likelihood bootstrap replicates (>70%) are indicated with an asterisk. Taxon information includes GenBank accession number and virus abbreviation. Branch colors are based on bornavirus species. The VSBV-1 sequence from the patient generated during this study and the highly similar VSBV-1 sequence from the zoo squirrel are shown in bold. Inset shows detail of mammalian 2 bornavirus section. Scale bars represent nucleotide substitutions per site.
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