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Volume 24, Number 6—June 2018
CME ACTIVITY - Research

Occupation-Associated Fatal Limbic Encephalitis Caused by Variegated Squirrel Bornavirus 1, Germany, 2013

Dennis TappeComments to Author , Kore Schlottau, Daniel Cadar, Bernd Hoffmann, Lorenz Balke, Burkhard Bewig, Donata Hoffmann, Philip Eisermann, Helmut Fickenscher, Andi Krumbholz, Helmut Laufs, Monika Huhndorf, Maria Rosenthal, Walter Schulz-Schaeffer, Gabriele Ismer, Sven-Kevin Hotop, Mark Brönstrup, Anthonina Ott, Jonas Schmidt-Chanasit1, and Martin Beer1
Author affiliations: Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany (D. Tappe, D. Cadar, P. Eisermann, M. Rosenthal, J. Schmidt-Chanasit); Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany (K. Schlottau, B. Hoffmann, D. Hoffmann, M. Beer); University Medical Center Schleswig-Holstein, Kiel, Germany (L. Balke, B. Bewig, H. Laufs, M. Huhndorf); Christian-Albrecht University of Kiel and University Medical Center, Kiel (H. Fickenscher, A. Krumbholz); Saarland University Medical Center, Homburg, Germany (W. Schulz-Schaeffer); Zoological Garden, Schleswig-Holstein, Germany (G. Ismer); Helmholtz Centre for Infection Research and German Centre for Infection Research, Braunschweig, Germany (S.-K. Hotop, M. Brönstrup); Euroimmun AG, Lübeck, Germany (A. Ott); German Centre for Infection Research, Hamburg (J. Schmidt-Chanasit)

Main Article

Table 1

Comparison of amino acid substitutions of human-derived variegated squirrel bornavirus 1 strain from a deceased zoo animal caretaker with those detected in exotic squirrels of 3 species and private squirrel breeders on the basis of protein coding region sequences*

Protein Human (Homo sapiens) BH55/16 Squirrel
 Unique substitutions
Sciurus variegatoides Callosciurus prevostii Tamiops swinhoei
N No No No No 0/0
X No No T120I No 1/1
P No L93I P21S, L93I L93I 1/2
M No No S71F No 1/1
G S175N, E185D,V228M, N390T S59P, E73K, S165G, T170A, N188D, V228M, S237P, R244K, V313I, N390S S19L, E60K, A106V, N111D, T170A, S175N/I, N188S, G196D, V228M, S237P, S238L, S254P, S332P, Y335S, N390T, I480M S59P, S237P, S238L 17/24
L I112V, L779F, T832I, G1365R, G1388S I112V, E143K, M166V, S360L, A756V, L779F, T832I, G1365R, G1388S K63R, I112V, N136S, A144T, M166V, V539I, A756V, L779F, T832I, I1053V, K1170L/R, Q1286H, G1365R, G1388S, P1423A, S1474L M166V, I194V, S360L 11/19

*Boldface indicates the unique amino acid substitutions detected in each host. Boldface and underlining indicate the mutation detected only in the variegated squirrel bornavirus 1 strain from the deceased animal caretaker (BH55/16; GenBank accession no. MF597762) and her contact squirrel (Callosciurus prevosti).

Main Article

1These authors contributed equally to this article.

Page created: May 18, 2018
Page updated: May 18, 2018
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