Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 24, Number 6—June 2018
CME ACTIVITY - Research

Occupation-Associated Fatal Limbic Encephalitis Caused by Variegated Squirrel Bornavirus 1, Germany, 2013

Dennis TappeComments to Author , Kore Schlottau, Daniel Cadar, Bernd Hoffmann, Lorenz Balke, Burkhard Bewig, Donata Hoffmann, Philip Eisermann, Helmut Fickenscher, Andi Krumbholz, Helmut Laufs, Monika Huhndorf, Maria Rosenthal, Walter Schulz-Schaeffer, Gabriele Ismer, Sven-Kevin Hotop, Mark Brönstrup, Anthonina Ott, Jonas Schmidt-Chanasit1, and Martin Beer1
Author affiliations: Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany (D. Tappe, D. Cadar, P. Eisermann, M. Rosenthal, J. Schmidt-Chanasit); Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany (K. Schlottau, B. Hoffmann, D. Hoffmann, M. Beer); University Medical Center Schleswig-Holstein, Kiel, Germany (L. Balke, B. Bewig, H. Laufs, M. Huhndorf); Christian-Albrecht University of Kiel and University Medical Center, Kiel (H. Fickenscher, A. Krumbholz); Saarland University Medical Center, Homburg, Germany (W. Schulz-Schaeffer); Zoological Garden, Schleswig-Holstein, Germany (G. Ismer); Helmholtz Centre for Infection Research and German Centre for Infection Research, Braunschweig, Germany (S.-K. Hotop, M. Brönstrup); Euroimmun AG, Lübeck, Germany (A. Ott); German Centre for Infection Research, Hamburg (J. Schmidt-Chanasit)

Main Article

Figure 3

Immunohistochemical and histologic slides of brain of patient who died of limbic encephalitis caused by variegated squirrel bornavirus 1 (VSBV-1), Germany, 2013. Immunohistochemistry of viral antigen in subcortical areas of the brain was performed by using a polyclonal antiserum against VSBV-1 N protein. Viral antigen was present in neurons and glial cells in nuclei and cytoplasm. A) Substantia nigra. Immunoperoxidase stain with hematoxylin counterstain; original magnification ×200. B) Striatum.

Figure 3. Immunohistochemical and histologic slides of brain of patient who died of limbic encephalitis caused by variegated squirrel bornavirus 1 (VSBV-1), Germany, 2013. Immunohistochemistry of viral antigen in subcortical areas of the brain was performed by using a polyclonal antiserum against VSBV-1 N protein. Viral antigen was present in neurons and glial cells in nuclei and cytoplasm. A) Substantia nigra. Immunoperoxidase stain with hematoxylin counterstain; original magnification ×200. B) Striatum. Immunoperoxidase stain with hematoxylin counterstain; original magnification ×200. C) Subcortical area next to the hypothalamus. Immunoperoxidase stain with hematoxylin counterstain; original magnification ×200. D) Subcortical area next to the hippocampus. Immunoperoxidase stain with hematoxylin counterstain; original magnification ×400. E) Intranuclear eosinophilic inclusion body resembling a bornavirus-like Joest-Degen body (arrow). Hematoxylin and eosin stain; original magnification ×600.

Main Article

1These authors contributed equally to this article.

Page created: May 18, 2018
Page updated: May 18, 2018
Page reviewed: May 18, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external