Volume 24, Number 9—September 2018
Seroprevalence of Chikungunya Virus after Its Emergence in Brazil
To the Editor: In their well-designed and timely serosurvey, Dias et al. provide evidence of high prevalence of East/Central/South African (ECSA) genotype chikungunya virus (CHIKV) (seropositivity rate 51.0%) in population subsets of 2 urban communities in Bahia state, Brazil (1). The authors found a high proportion of asymptomatic CHIKV patients (63.2%; 268/424). In addition, the prevalence of chronic arthralgia among infected persons (26.4%; 112/424) was lower or within the expected range of previously reemerging clades of CHIKV, namely ECSA diverged (Indian Ocean lineage) or Asian lineage, respectively. However, a high proportion of the symptomatic participants in Dias et al. reported chronic symptoms lasting >3 months (71.8%; 112/156). We comment on these findings.
First, Dias et al. report that the selected locations were at the epicenter of the transmission area and, therefore, the data cannot be extrapolated to other cities. To better understand the dynamics of the disease, it would be useful to select locations more representative of other infected areas.
Second, the modest participation at the study locations (66.5%; 831/1250) could be related to using the more painful venipuncture method instead of a fingerstick to draw blood. In comparison, the participation rate was ≈80% in a Réunion Island serosurvey for CHIKV for which the fingerstick method was used (2). The participation level suggests the possibility of self-selection bias toward infected patients, who might be more interested in knowing their serologic status. Self-selection bias might explain the high proportion of symptomatic patients who self-reported having a chronic form of chikungunya.
Last, because of their unreliable discriminatory performance, using fever and arthralgia to identify symptomatic patients might have increased the proportion of patients misclassified as asymptomatic (i.e., patients with symptoms other than fever and arthralgia being falsely classified as negative) (3). These limitations being specified, the prevalence of chronic arthralgia among symptomatic patients in Dias et al. falls within the expected range of the Asian lineage of CHIKV, the other clade circulating in the Americas (4,5), which confers external validity to the study.
- Dias JP, Costa MDCN, Campos GS, Paixão ES, Natividade MS, Barreto FR, et al. Seroprevalence of chikungunya virus after its emergence in Brazil. Emerg Infect Dis. 2018;24:617–24. DOIPubMedGoogle Scholar
- Gérardin P, Guernier V, Perrau J, Fianu A, Le Roux K, Grivard P, et al. Estimating Chikungunya prevalence in La Réunion Island outbreak by serosurveys: two methods for two critical times of the epidemic. BMC Infect Dis. 2008;8:99. DOIPubMedGoogle Scholar
- Sissoko D, Ezzedine K, Moendandzé A, Giry C, Renault P, Malvy D. Field evaluation of clinical features during chikungunya outbreak in Mayotte, 2005-2006. Trop Med Int Health. 2010;15:600–7.PubMedGoogle Scholar
- Chang AY, Encinales L, Porras A, Pacheco N, Reid SP, Martins KAO, et al. Frequency of chronic joint pain following chikungunya virus infection: a Colombian cohort study. Arthritis Rheumatol. 2018;70:578–84. DOIPubMedGoogle Scholar
- Paixão ES, Rodrigues LC, Costa MDCN, Itaparica M, Barreto F, Gérardin P, et al. Chikungunya chronic disease: a systematic review and meta-analysis. Trans R Soc Trop Med Hyg. 2018;112:301–16. DOIPubMedGoogle Scholar
Original Publication Date: July 31, 2018
1All authors contributed equally to this article.
Table of Contents – Volume 24, Number 9—September 2018
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Please use the form below to submit correspondence to the authors or contact them at the following address:
Patrick Gérardin, INSERM CIC 1410 Clinical Epidemiology, Centre Hospitalier Universitaire, Groupe Hospitalier Sud Réunion, BP 350, 97448 Saint Pierre CEDEX, Reunion, France