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Volume 25, Number 1—January 2019
Research

Effects of Antibiotic Cycling Policy on Incidence of Healthcare-Associated MRSA and Clostridioides difficile Infection in Secondary Healthcare Settings

Geraldine Mary Conlon-Bingham1Comments to Author , Mamoon Aldeyab, Michael Scott, Mary Patricia Kearney, David Farren, Fiona Gilmore, and James McElnay
Author affiliations: Queen’s University Belfast, Belfast, Northern Ireland, UK (G.M. Conlon-Bingham, J. McElnay); Antrim Hospital, Antrim, Northern Ireland, UK (M. Aldeyab); Ulster University, Coleraine, Northern Ireland, UK (M. Aldeyab); Northern Health and Social Care Trust, Antrim (M. Scott, M.P. Kearney, D. Farren, F. Gilmore)

Main Article

Table 2

Segmented regression analysis of the incidence of HA-CDI, HA-MRSA, and infections caused by new ESBL isolates in a hospital with a cycling policy and a hospital with a standard policy, Northern Ireland, UK*

Variable
 AAH, cycling policy
CH, standard policy
Coefficient
 95% CI
 SE
 p value
 Coefficient
 95% CI
 SE
 p value
HA-CDI
Constant 0.0236 0.0099 to 0.0373 0.0068 <0.01 −2.9873† −3.669 to −2.3055 0.3378 <0.01
Trend 9.34 × 10−5 −0.0009 to 0.0011 0.0005 0.85 −0.01905† –0.0603 to 0.0222 0.0204 0.36
Change
In level −0.0084 −0.0270 to 0.0102 0.0092 0.36 −0.1335† −0.6324 to 0.3654 0.2472 0.59
In trend
 0.0004
 −0.0010 to 0.0017
 0.0007
 0.58
0.0053†
 −0.0394 to 0.0500
 0.0221
 0.81
HA-MRSA
Constant 0.1100 0.0856 to 0.1343 0.0121 <0.01 0.0849 0.0562 to 0.1135 0.01421 <0.01
Trend −2.96 × 10−3 −0.0047 to −0.0012 0.0009 <0.01 −0.0008 −0.0029 to 0.0013 0.0010 0.46
Change
In level 0.0196 −0.0134 to 0.05261 0.01634 0.24 0.0230 −0.0158 to 0.0618 0.01925 0.24
In trend
 0.0041
 0.0017–0.0066
 0.0012
 <0.01
−0.0005
 −0.0034 to 0.0023
 0.0014
 0.72
New ESBL
Constant −3.7851† −4.3481 to −3.2222 0.2790 <0.01 0.0370 0.0119 to 0.0621 0.0124 <0.01
Trend −0.0018† −0.0428 to 0.0393 0.0203 0.93 −0.0004 −0.0023 to 0.0015 0.0009 0.68
Change
In level 0.4846† −0.2776 to 1.2469 0.3777 0.21 −0.0093 −0.0440 to 0.0045 0.0172 0.59
In trend 0.0099† −0.0464 to 0.0662 0.0279 0.72 0.0019 −0.0006 to 0.1564 0.0013 0.13
Outlier at 2013 Jul, CH only NA NA NA NA 0.0949 0.0333 to 0.1564 0.0305 <0.01

*Bold indicates statistical significance. AAH, Antrim Area Hospital; CH, Causeway Hospital; CDI, Clostridioides difficile infection; ESBL, extended-spectrum β-lactamase; HA, healthcare-associated; MRSA, methicillin-resistant Staphylococcus aureus; NA, not applicable.
†Data logarithmically transformed.

Main Article

1Current affiliation: Craigavon Area Hospital, Craigavon, Northern Ireland, UK.

Page created: December 17, 2018
Page updated: December 17, 2018
Page reviewed: December 17, 2018
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