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Volume 25, Number 1—January 2019

Effects of Antibiotic Cycling Policy on Incidence of Healthcare-Associated MRSA and Clostridioides difficile Infection in Secondary Healthcare Settings

Geraldine Mary Conlon-Bingham1Comments to Author , Mamoon Aldeyab, Michael Scott, Mary Patricia Kearney, David Farren, Fiona Gilmore, and James McElnay
Author affiliations: Queen’s University Belfast, Belfast, Northern Ireland, UK (G.M. Conlon-Bingham, J. McElnay); Antrim Hospital, Antrim, Northern Ireland, UK (M. Aldeyab); Ulster University, Coleraine, Northern Ireland, UK (M. Aldeyab); Northern Health and Social Care Trust, Antrim (M. Scott, M.P. Kearney, D. Farren, F. Gilmore)

Main Article

Table 4

Changes in resistance patterns of healthcare-associated methicillin-resistant Staphylococcus aureus clinical isolates, Northern Ireland, UK*

Antibiotic comparison
AAH, no. resistant isolates/total tested (%)
CH, no. resistant isolates/total tested (%)
Preintervention resistance
Intervention resistance
p value
Preintervention resistance
Intervention resistance
p value
Preintervention vs. intervention
Amoxicillin/clavulanic acid 2/2 (100) 2/2 (100) NA 2/2 (100) 0 NA
Piperacillin/tazobactam 1/1 (100) 1/1 (100) NA 1/1 (100) 0 NA
Ciprofloxacin 66/66 (100) 77/78 (98.7) 0.99 31/31 (100) 33/34 (97.1) 0.17
54/70 (77.1)
69/80 (86.3)

23/32 (71.9)
22/35 (65.9)
Intervention vs. postintervention
Amoxicillin/clavulanic acid 2/2 (100) 2/2 (100) NA NR NR NR
Piperacillin/tazobactam 1/1 (100) 0 NA NR NR NR
Ciprofloxacin 77/78 (98.7) 27/27 (100) 0.74 NR NR NR
Erythromycin 69/80 (86.3) 23/28 (82.1) 0.40 NR NR NR

*In AAH (antibiotic cycling policy) and CH (standard antibiotic policy), the preintervention period was November 2011–September 2013, and the intervention period was October 2013–September 2015. In AAH, the postintervention period was October 2015–September 2016. AAH, Antrim Area Hospital; CH, Causeway Hospital; NA, no isolates tested against amoxicillin/clavulanic acid and piperacillin/tazobactam; NR, data not recorded.

Main Article

1Current affiliation: Craigavon Area Hospital, Craigavon, Northern Ireland, UK.

Page created: December 17, 2018
Page updated: December 17, 2018
Page reviewed: December 17, 2018
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