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Volume 25, Number 1—January 2019

Effects of Antibiotic Cycling Policy on Incidence of Healthcare-Associated MRSA and Clostridioides difficile Infection in Secondary Healthcare Settings

Geraldine Mary Conlon-Bingham1Comments to Author , Mamoon Aldeyab, Michael Scott, Mary Patricia Kearney, David Farren, Fiona Gilmore, and James McElnay
Author affiliations: Queen’s University Belfast, Belfast, Northern Ireland, UK (G.M. Conlon-Bingham, J. McElnay); Antrim Hospital, Antrim, Northern Ireland, UK (M. Aldeyab); Ulster University, Coleraine, Northern Ireland, UK (M. Aldeyab); Northern Health and Social Care Trust, Antrim (M. Scott, M.P. Kearney, D. Farren, F. Gilmore)

Main Article

Table 3

Segmented regression analysis of effect of stopping cycling on the incidence of HA-CDI, HA-MRSA, and new ESBL isolates in Antrim Area Hospital, Northern Ireland, UK*

Variable Coefficient 95% CI SE p value
Constant 0.0173 0.0062 to 0.0284 0.0054 <0.01
Trend 4.73 × 10−4 −0.0003 to 0.0012 0.0004 0.22
In level −0.0159 −0.0352 to 0.0033 0.0094 0.10
In trend
−0.0018 to 0.0028
Constant 0.0598 0.0388 to 0.0810 0.0102 <0.01
Trend 0.0012 −0.0002 to 0.0027 0.0007 0.10
In level −0.0350 −0.0711 to −0.001 0.0179 0.06
In trend
−0.002 to 0.0027
Constant 0.0438 0.0200 to 0.0672 0.0115 <0.01
Trend 0.0005 −0.0011 to 0.0021 0.0008 0.56
In level 0.0419 0.0017 to 0.0820 0.0199 0.04
In trend −0.0026 −0.0074 to 0.0023 0.0024 0.30

*In this hospital, a cycling policy was in place during October 2013–September 2015, and a standard policy was in place during October 2015–September 2016. Bold indicates statistical significance. ESBL, extended-spectrum β-lactamase; HA-CDI, healthcare-associated Clostridioides difficile infection; HA-MRSA, healthcare-associated methicillin-resistant Staphylococcus aureus.

Main Article

1Current affiliation: Craigavon Area Hospital, Craigavon, Northern Ireland, UK.

Page created: December 17, 2018
Page updated: December 17, 2018
Page reviewed: December 17, 2018
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