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Volume 25, Number 11—November 2019
Research

Molecular and Clinical Comparison of Enterovirus D68 Outbreaks among Hospitalized Children, Ohio, USA, 2014 and 2018

Huanyu Wang, Alejandro Diaz, Katherine Moyer1, Maria Mele-Casas2, Maria Fatima Ara-Montojo3, Isabel Torrus2, Karen McCoy, Asuncion Mejias, and Amy L. LeberComments to Author 
Author affiliations: Nationwide Children’s Hospital, Columbus, Ohio, USA (H. Wang, A. Diaz, K. Moyer, M. Mele-Casas, M.F. Ara-Montojo, I. Torrus, K. McCoy, A. Mejias, A.L. Leber); The Ohio State University, Columbus, Ohio, USA (H. Wang, A. Mejias, A.L. Leber)

Main Article

Figure 1

Sample and patient selection for investigation of EV-D68 outbreaks, Columbus, Ohio, USA. Viral testing was conducted at Nationwide Children’s Hospital Department of Pathology. During May–November 2014, a total of 3,540 samples underwent viral testing, of which 41% tested positive for RV/EV by a single or multiplex PCR. Four hundred fifty-nine samples were selected randomly on the basis of availability, integrity, and amount of specimen, of which 44% were positive for EV-D68. During May–October 2

Figure 1. Sample and patient selection for investigation of EV-D68 outbreaks, Columbus, Ohio, USA. Viral testing was conducted at Nationwide Children’s Hospital Department of Pathology. During May–November 2014, a total of 3,540 samples underwent viral testing, of which 41% tested positive for RV/EV by a single or multiplex PCR. Four hundred fifty-nine samples were selected randomly on the basis of availability, integrity, and amount of specimen, of which 44% were positive for EV-D68. During May–October 2018, a total of 3,633 samples were tested for RV/EV by FilmArray Respiratory Panel v1.7 (6); 1,987 (55%) were positive. Of the 1,025 convenience samples, 401 (39%) were positive for EV-D68. After samples for which clinical data were not available, for which patient age was >21 years, or for which EV-D68 was acquired nosocomially were excluded, 192 case-patients from the 2014 outbreak and 278 from the 2018 outbreak were included in the analyses. EV-D68, enterovirus D68; RV/EV, rhinovirus/enterovirus.

Main Article

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Main Article

1Current affiliation: Inova Fairfax Hospital, Falls Church, Virginia, USA.

2Current affiliation: Hospital Sant Joan de Deu, Barcelona, Spain.

3Current affiliation: Hospital Universitario La Paz, Madrid, Spain.

Page created: October 15, 2019
Page updated: October 15, 2019
Page reviewed: October 15, 2019
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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