Volume 25, Number 11—November 2019
Research
Molecular and Clinical Comparison of Enterovirus D68 Outbreaks among Hospitalized Children, Ohio, USA, 2014 and 2018
Huanyu Wang, Alejandro Diaz, Katherine Moyer1, Maria Mele-Casas2, Maria Fatima Ara-Montojo3, Isabel Torrus2, Karen McCoy, Asuncion Mejias, and Amy L. Leber
Table 2
Demographic and clinical characteristics of children with EV-D68 infection, Nationwide Children’s Hospital, Columbus, Ohio, USA, 2014 and 2018 outbreaks*
| Clinical presentation and disease severity, no. (%) | |||
|---|---|---|---|
| Respiratory | 192 (100) | 271 (97.8) | 0.08 |
| Fever | 106 (55.2) | 142 (51.3) | 0.45 |
| Neurologic | 4 (2.1) | 8 (2.9) | 0.57 |
| AFM/OMS | 0 | 3 (1.1) | 0.27 |
| Other: seizures | 4 (2.1) | 5 (1.8) | >0.99 |
| Gastrointestinal | 24 (12.5) | 79 (28.5) | <0.0001 |
| Rash |
10 (5.2) |
4 (1.4) |
0.02 |
| PICU admission, no. (%) | 131 (68.2) | 136 (49.1) | <0.0001 |
| Hospitalization, d (IQR) | 2.8 (1.9–4.2) | 2.5 (1.6–3.8) | 0.01 |
*Bold indicates significance. AFM/OMS, acute flaccid myelitis/opsoclonus/myoclonus syndrome; EV-D68, enterovirus D68; IQR, interquartile range; PICU, pediatric intensive care unit.
†Comprises genetic syndromes, congenital heart disease, history of prematurity, neurologic disorders, neuromuscular disorders.
1Current affiliation: Inova Fairfax Hospital, Falls Church, Virginia, USA.
2Current affiliation: Hospital Sant Joan de Deu, Barcelona, Spain.
3Current affiliation: Hospital Universitario La Paz, Madrid, Spain.
Page created: October 15, 2019
Page updated: October 15, 2019
Page reviewed: October 15, 2019
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