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Volume 25, Number 11—November 2019
Research

Molecular and Clinical Comparison of Enterovirus D68 Outbreaks among Hospitalized Children, Ohio, USA, 2014 and 2018

Huanyu Wang, Alejandro Diaz, Katherine Moyer1, Maria Mele-Casas2, Maria Fatima Ara-Montojo3, Isabel Torrus2, Karen McCoy, Asuncion Mejias, and Amy L. LeberComments to Author 
Author affiliations: Nationwide Children’s Hospital, Columbus, Ohio, USA (H. Wang, A. Diaz, K. Moyer, M. Mele-Casas, M.F. Ara-Montojo, I. Torrus, K. McCoy, A. Mejias, A.L. Leber); The Ohio State University, Columbus, Ohio, USA (H. Wang, A. Mejias, A.L. Leber)

Main Article

Table 2

Demographic and clinical characteristics of children with EV-D68 infection, Nationwide Children’s Hospital, Columbus, Ohio, USA, 2014 and 2018 outbreaks*

Clinical presentation and disease severity, no. (%)
Respiratory 192 (100) 271 (97.8) 0.08
Fever 106 (55.2) 142 (51.3) 0.45
Neurologic 4 (2.1) 8 (2.9) 0.57
AFM/OMS 0 3 (1.1) 0.27
Other: seizures 4 (2.1) 5 (1.8) >0.99
Gastrointestinal 24 (12.5) 79 (28.5) <0.0001
Rash
10 (5.2)
4 (1.4)
0.02
PICU admission, no. (%) 131 (68.2) 136 (49.1) <0.0001
Hospitalization, d (IQR) 2.8 (1.9–4.2) 2.5 (1.6–3.8) 0.01

*Bold indicates significance. AFM/OMS, acute flaccid myelitis/opsoclonus/myoclonus syndrome; EV-D68, enterovirus D68; IQR, interquartile range; PICU, pediatric intensive care unit.
†Comprises genetic syndromes, congenital heart disease, history of prematurity, neurologic disorders, neuromuscular disorders.

Main Article

1Current affiliation: Inova Fairfax Hospital, Falls Church, Virginia, USA.

2Current affiliation: Hospital Sant Joan de Deu, Barcelona, Spain.

3Current affiliation: Hospital Universitario La Paz, Madrid, Spain.

Page created: October 15, 2019
Page updated: October 15, 2019
Page reviewed: October 15, 2019
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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