Volume 25, Number 11—November 2019
Research
Molecular and Clinical Comparison of Enterovirus D68 Outbreaks among Hospitalized Children, Ohio, USA, 2014 and 2018
Huanyu Wang, Alejandro Diaz, Katherine Moyer1, Maria Mele-Casas2, Maria Fatima Ara-Montojo3, Isabel Torrus2, Karen McCoy, Asuncion Mejias, and Amy L. Leber
Table 1
Demographic and clinical characteristics of children with EV-D68 infection, Nationwide Children’s Hospital, Columbus, Ohio, USA, 2018*
| Characteristics | Previously healthy, n = 67 | Chronic medical condition, n = 64 | Asthma, n = 146 | p value |
|---|---|---|---|---|
| Median age, y (IQR) |
1.4 (0.9–4.0) |
2.5 (1.1–6.9) |
4.1 (2.1–7.5) |
<0.0001 |
| Sex, no. (%) | ||||
| M | 31 (46.3) | 36 (56.2) | 84 (57.5) | 0.29 |
| F |
36 (53.7) |
28 (43.8) |
62 (42.5) |
|
| Race, no. (%) | ||||
| White | 42 (62.7) | 43 (67.2) | 84 (57.5) | 0.12 |
| Black | 14 (20.9) | 13 (20.3) | 50 (33.5) | |
| Other |
11 (16.4) |
8 (12.5) |
13 (8.9) |
|
| PICU admission, no. (%) | 25 (37.3) | 19 (29.7) | 92 (63) | <0.0001 |
| Median hospitalization, d (IQR) |
1.8 (1–3) |
3.2 (1.5–8) |
2.5 (1.7–3.5) |
0.003 |
| Signs/symptoms, no. (%) | ||||
| Respiratory | 64 (95.5) | 60 (93.8) | 146 (100) | 0.01 |
| Fever | 39 (58.2) | 36 (56.3) | 67 (45.8) | 0.16 |
| Neurologic | 4 (5.9) | 3 (4.7) | 1 (0.7) | 0.06 |
| Gastrointestinal | 18 (26.8) | 20 (31.3) | 40 (27.4) | 0.81 |
| Rash |
3 (4.5) |
0 |
1 (0.7) |
0.05 |
| Median EV-D68 Ct (IQR) | 26.1 (22.2–30.3) | 25.5 (22.2–28.8) | 25.1 (22–38.5) | 0.67 |
*Bold indicates significance. Ct, cycle threshold; EV-D68, enterovirus D68; IQR, interquartile range; PICU, pediatric intensive care unit.
1Current affiliation: Inova Fairfax Hospital, Falls Church, Virginia, USA.
2Current affiliation: Hospital Sant Joan de Deu, Barcelona, Spain.
3Current affiliation: Hospital Universitario La Paz, Madrid, Spain.
Page created: October 15, 2019
Page updated: October 15, 2019
Page reviewed: October 15, 2019
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