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Volume 25, Number 4—April 2019

Research

Sand Fly–Associated Phlebovirus with Evidence of Neutralizing Antibodies in Humans, Kenya

David P. TchouassiComments to Author , Marco Marklewitz, Edith Chepkorir, Florian Zirkel1, Sheila B. Agha, Caroline C. Tigoi, Edith Koskei, Christian Drosten, Christian Borgemeister, Baldwyn Torto, Sandra Junglen2Comments to Author , and Rosemary Sang2
Author affiliations: International Centre of Insect Physiology and Ecology, Nairobi, Kenya (D.P. Tchouassi, E. Chepkorir, S.B. Agha, C.C. Tigoi, B. Torto, R. Sang); Charité-Universitätsmedizin Berlin, Berlin, Germany (M. Marklewitz, F. Zirkel, C. Drosten, S. Junglen); German Center for Infection Research, Berlin (M. Marklewitz, F. Zirkel, C. Drosten, S. Junglen); Center for Virus Research, Kenya Medical Research Institute, Nairobi (E. Koskei, R. Sang); University of Bonn, Bonn, Germany (C. Borgemeister)

Main Article

Figure 3

Phylogenetic relationship of novel sand fly–associated phlebovirus Ntepes virus from Kenya (red bold text) in relation to other selected members of the Phlebovirus genus. A) RNA-dependent RNA polymerase; B) nucleocapsid protein; C) glycoprotein Gn; D) glycoprotein Gc. The phylogenetic trees were inferred based on complete large, medium, and small protein sequences, applying maximum likelihood analysis in PhyML version 3.0 (http://www.atgc-montpellier.fr/phyml/versions.php) using the LG substitu

Figure 3. Phylogenetic relationship of novel sand fly–associated phlebovirus Ntepes virus from Kenya (red bold text) in relation to other selected members of the Phlebovirus genus. A) RNA-dependent RNA polymerase; B) nucleocapsid protein; C) glycoprotein Gn; D) glycoprotein Gc. The phylogenetic trees were inferred based on complete large, medium, and small protein sequences, applying maximum likelihood analysis in PhyML version 3.0 (http://www.atgc-montpellier.fr/phyml/versions.php) using the LG substitution model. Statistical support of the tree topology was evaluated by bootstrap resampling of the sequences 1,000 times. Sequences are identified by virus name and branch colors. Bootstrap values >70 are indicated at the nodes. Scale bar represents numbers of substitutions per site.

Main Article

1Current affiliation: Biotest AG, Dreieich, Germany.

2These authors contributed equally to this article.

Page created: March 17, 2019
Page updated: March 17, 2019
Page reviewed: March 17, 2019
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