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Volume 25, Number 5—May 2019
Dispatch

Genetic Characterization of Middle East Respiratory Syndrome Coronavirus, South Korea, 2018

Yoon-Seok Chung, Jeong Min Kim, Heui Man Kim, Kye Ryeong Park, Anna Lee, Nam-Joo Lee, Mi-Seon Kim, Jun Sub Kim, Chi-Kyeong Kim, Jae In Lee, and Chun KangComments to Author 
Author affiliations: Korea Centers for Disease Control and Prevention, Cheongju, South Korea (Y.-S. Chung, J.M. Kim, H.M. Kim, K.R. Park, A. Lee, N.-J. Lee, M.-S. Kim, J.S. Kim, C.-K. Kim, C. Kang); Seoul Institute of Public Health and Environment, Seoul, South Korea (J.I. Lee)

Main Article

Table

Comparison of spike glycoprotein gene sequence variants for a MERS-CoV isolates from a patient in South Korea, 2018, and reference strains*

MERS-CoV strain
Nucleotide (amino acid) positions
NTD

RBD

Other regions
183 (61)
258 (86)
409 (137)
1586 (529)
1588 (530)
1848 (616)
1886 (629)
3177 (1059)
3267 (1089)
JX869059_HCoV-EMC_2012† C (G) T (V) A (S) T (I) G (V) T (V) G (R) T (D) C (S)
KR011266_KSA_Hu/Riyadh-KSA-2049/2015 C (V)
KR011263_KSA_Hu/Riyadh-KSA-2345/2015 C (V)
KR011264_KSA_Hu/Riyadh-KSA-2343/2015 C (V)
KR011265_KSA_Hu/Riyadh-KSA-2466/2015 C (V)
KT026453_KSA_Hu/Riyadh-KSA-2959/2015 C (V)
KT026454_KSA_Hu/Riyadh_KSA_4050/2015 C (V)
KX154690_Hu_Jeddah-KSA-161RS1146_2016 C (V)
KX154684_Hu-Riyadh-KSA-11739_2016 C (V)
KX154694_Hu-Artawiyah-KSA-13328_2016 C (V)
MG011361_Hu-Riyadh-KSA-K17000405_2017 C (V)
MG011360_Hu-Riyadh-KSA-K17000887_2017 C (V)
MG912608_Hu-Riyadh-KSA-9730_2017 C (V)
MERS-CoV/KOR/KNIH/001_05_2015 C (V) C (T) C (D) T (S)
KT029139-MERS-CoV/KOR/KNIH/002_05_2015 C (V) C (R) C (L) C (D) T (S)
MERS-CoV/KOR/KNIH/009_05_2015 C (V) C (V) C (D) T (S)
KT006149-ChinaGD01_2015 G (G) C (V) C (V) C (D) T (S)
MERS-CoV/KOR/KNIH/012_05_2015 C (V) C (T) C (V) C (D) T (S)
MERS-CoV/KOR/KNIH/013_05_2015 C (V) C (T) C (V) C (D) T (S)
MERS-CoV/KOR/KNIH/015_05_2015 C (V) C (T) C (V) A (H) C (D) T (S)
MERS-CoV/KOR/KNIH/042_04_2015 C (V) C (D) T (S)
MERS-CoV/KOR/KCDC/001_2018_2SP-1 C (V)
MERS-CoV/KOR/KCDC/001_2018_4TS C (V)
MERS-CoV/KOR/KCDC/001_2018_4TSVi C (V)

*Only variations from the reference strain are shown. Boldface indicates the South Korea isolates and the most similar strain identified in this study. MERS-CoV, Middle East respiratory syndrome coronavirus; NTD, N-terminal domain; RBD, receptor-binding domain.
†Reference MERS-CoV strain.

Main Article

Page created: April 17, 2019
Page updated: April 17, 2019
Page reviewed: April 17, 2019
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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