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Volume 25, Number 6—June 2019
Research

Phenotypic and Genomic Analyses of Burkholderia stabilis Clinical Contamination, Switzerland

Helena M.B. Seth-SmithComments to Author , Carlo Casanova, Rami Sommerstein, Dominik M. Meinel1, Mohamed M.H. Abdelbary2, Dominique S. Blanc, Sara Droz, Urs Führer, Reto Lienhard, Claudia Lang, Olivier Dubuis, Matthias Schlegel, Andreas Widmer, Peter M. Keller3, Jonas Marschall, and Adrian EgliComments to Author 
Author affiliations: University Hospital Basel, Basel, Switzerland (H.M.B. Seth-Smith, D.M. Meinel, A. Widmer, A. Egli); University of Basel, Basel (H.M.B. Seth-Smith, D.M. Meinel, A. Egli); University of Bern, Bern, Switzerland (C. Casanova, S. Droz); Bern University Hospital, Bern (R. Sommerstein, J. Marschall); Lausanne University Hospital, Lausanne, Switzerland (M.M.H. Abdelbary, D.S. Blanc); Biel Hospital, Biel, Switzerland (U. Führer); ADMED, La Chaux-de-Fonds, Switzerland (R. Lienhard); Viollier AG, Allschwil, Switzerland (C. Lang, O. Dubuis); Cantonal Hospital St. Gallen, St. Gallen, Switzerland (M. Schlegel); Swissnoso, National Center for Infection Prevention, Bern (M. Schlegel, A. Widmer, J. Marschall); University of Zurich, Zurich, Switzerland (P.M. Keller)

Main Article

Table 2

Genome comparisons of Burkholderia stabilis outbreak strain CH16 from Switzerland against Burkholderia reference strains*

Reference genome Genomovar GenBank accession nos. ANI,† 
1-way,% dDDH,‡ formula 2 Probability dDDH >70% % G+C difference
B. stabilis ATCC BAA-67 IV CP016442–4 98.4 87.8 94.98 0.08
B. pyrrocinina DSM10685 IX CP011503–6 92.9 49.4 17.44 0.17
B. stabilis LA20W§ IV GCA_001685505.1 92.5 49.3 17.3 0.16
B. lata 383 NC_007509–11 91.4 44.7 7.72 0.12
B. cepacia ATCC25416 I NZ_CP012981–3 91.3 44.5 7.52 0.37
B. cenocepacia J2315 III AM747720–3 91.1 44 6.68 0.55
B. ambifaria AMMD VII NZ_CP009798–800 89.8 39.9 2.65 0.44
B. latens AU17928 CP013435–8 88.8 37 1.22 0.03
B. dolosa AU0158 VI CP009793–5 88.8 37.2 1.27 0.66
B. vietnamensis LMG10929 V CP009629–32 88.5 36.2 0.97 0.48
B. multivorans DDS 15A-1 II CP008728–30 88.3 36 0.89 0.25
B. multivorans BAA247 II CP009830–2 88.1 35.3 0.71 0.9

*ANI, average nucleotide identity; dDDH, digital DNA-DNA hybridization.
†Species cutoff 95%.
‡Species cutoff 70%.
§From these results, strain LA20W should not be classified as B. stabilis.

Main Article

1Current affiliation: Genetics and Genomics at Roche, Basel, Switzerland.

2Current affiliation: RWTH Aachen University Hospital, Aachen, Germany.

3Current affiliation: University of Bern, Bern, Switzerland

Page created: May 20, 2019
Page updated: May 20, 2019
Page reviewed: May 20, 2019
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