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Volume 25, Number 6—June 2019
Dispatch

Scrub Typhus in Continental Chile, 2016–20181

Thomas WeitzelComments to Author , Katia AbarcaComments to Author , Constanza Martínez-Valdebenito, Gerardo Acosta-Jamett, Ju Jiang, and Allen L. Richards
Author affiliations: Clinica Alemana, Universidad del Desarrollo, Santiago, Chile (T. Weitzel); Pontificia Universidad Católica de Chile, Santiago (C. Martínez-Valdebenito, K. Abarca); Universidad Austral de Chile, Valdivia, Chile (G. Acosta-Jamett); Naval Medical Research Center, Silver Spring, Maryland, USA (J. Jiang, A.L. Richards)

Main Article

Table 2

Serologic and molecular diagnosis of scrub typhus cases in continental Chile, 2016–2018*

Case no. Serologic testing results
 Eschar molecular testing results
IFA IgG†
 ELISA IgG‡
 ELISA IgM‡
 PCR rrs PCR 47kDa qPCR rrs
Acute Conv Acute Conv Acute Conv
1 256 256 + + + – + + +
2 <32 128 – – – – + + +
3 64 512 – + + – + + +
4 128 256 – – – – + + +
5 128 NA + NA + NA + + +
6 128 NA – NA – NA + + +
7 128 256 – + + + + + +
8 <32 NA + NA + NA + + +
9 64 256 – + – + + + +

*Acute, acute-phase; conv, convalescent-phase; NA, not available; qPCR; real-time PCR; +, positive; –, negative.
†Highest titer among four antigens
‡Cutoffs values calculated as mean optical density of negative local population + 3 SD.

Main Article

1Preliminary results from this study were presented at the 67th Annual Meeting of the American Society of Tropical Medicine and Hygiene, October 28–November 2, 2018, New Orleans, Louisiana, USA.

Page created: May 20, 2019
Page updated: May 20, 2019
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