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Volume 26, Number 11—November 2020
Research

Endotheliopathy and Platelet Dysfunction as Hallmarks of Fatal Lassa Fever

Lucy E. Horton1, Robert W. Cross1, Jessica N. Hartnett, Emily J. Engel, Saori Sakabe, Augustine Goba, Mambu Momoh, John Demby Sandi, Thomas W. Geisbert, Robert F. Garry, John S. Schieffelin, Donald S. Grant, and Brian M. SullivanComments to Author 
Author affiliations: The Scripps Research Institute, La Jolla, California, USA (L.E. Horton, S. Sakabe, B.M. Sullivan); University of Texas Medical Brach, Galveston, Texas, USA (R.W. Cross, T.W. Geisbert); Tulane University School of Medicine, New Orleans, Louisiana, USA (J.N. Hartnett, E.J. Engel, R.F. Garry, J.S. Schieffelin); Kenema Government Hospital, Kenema, Sierra Leone (A. Goba, M. Momoh, J.D. Sandi, D.S. Grant); Ministry of Health and Sanitation, Freetown, Sierra Leone (A. Goba, M. Momoh, J.D. Sandi); Eastern Polytechnic Institute, Kenema (M. Momoh, D.S. Grant); Njala University, Moyamba, Sierra Leone (J.D. Sandi); University of Sierra Leone, Freetown (D.S. Grant)

Main Article

Figure 1

Clinical features suggestive of vascular permeability in patients with Lassa fever, Sierra Leone, 2015–2018. Patients with acute LF who had >2 signs or symptoms indicating vascular permeability at the time of admission were more likely to have fatal outcomes based on multiple logistic regression compared with patients who had no of symptoms vascular permeability (p = 0.0335). Case-fatality rates associated with various signs and symptoms are shown at the top and violin plot depicting the number of persons in each category at the bottom (median value indicated by dotted vertical lines). CFR, case-fatality rate; E, generalized edema; MB, mucosal membrane bleeding; RS, respiratory symptoms, such as cough or pulmonary edema.

Figure 1. Clinical features suggestive of vascular permeability in patients with Lassa fever, Sierra Leone, 2015–2018. Patients with acute LF who had >2 signs or symptoms indicating vascular permeability at the time of admission were more likely to have fatal outcomes based on multiple logistic regression compared with patients who had no of symptoms vascular permeability (p = 0.0335). Case-fatality rates associated with various signs and symptoms are shown at the top and violin plot depicting the number of persons in each category at the bottom (median value indicated by dotted vertical lines). CFR, case-fatality rate; E, generalized edema; MB, mucosal membrane bleeding; RS, respiratory symptoms, such as cough or pulmonary edema.

Main Article

1These authors contributed equally to this article.

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