Figure 6. P-selectin and adhesion molecule levels in patients with acute LF, NLFCs, and healthy controls (HCs), Sierra Leone, 2015–2018. A) Differences in soluble P-selectin (CD62P) were statistically significant (Kruskal-Wallis p = 0.0358), but we found no statistically significant differences when comparing groups to each other using Dunn’s multiple comparisons test (left, middle); no statistically significant correlation was observed between P-selectin and LASV-Ag levels (n = 15). B) Statistically significant differences in soluble ICAM levels were noted across all groups (Kruskal-Wallis p<0.0001). ICAM was statistically significantly elevated (****p<0.0001) in acute LF (n = 34) compared with HCs (n = 41) and NLFCs (n = 44; **p = 0.0036). No statistically significant correlation was found between ICAM and LASV antigen (n = 14) C) Statistically significant differences in soluble VCAM levels were observed across all groups (Kruskal-Wallis p = 0.0052). VCAM was statistically significantly elevated (*p = 0.0127) in acute LF (n = 34) compared with HCs (n = 41). No statistically significant differences were observed in acute LF patients who survived (n = 6) compared with those who died (n = 21) and no statistically significant correlation was found between VCAM and LASV-Ag (n = 14). Limits of detection are indicated by dashed lines and gray shading below. Error bars show SDs; horizontal lines indicate means. D, died; HC, healthy controls; ICAM, intercellular adhesion molecule; LF, Lassa fever; LASV, Lassa fever virus; LASV-Ag, Lassa fever virus antigen; NLFC, non–LF febrile controls; S, survived; VCAM, vascular cell adhesion molecule.
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