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Volume 26, Number 12—December 2020
Dispatch

Transmission of Multidrug-Resistant Salmonella enterica Subspecies enterica 4,[5],12:i:- Sequence Type 34 between Europe and the United States

Ehud ElnekaveComments to Author , Samuel L. Hong, Seunghyun Lim, Dave Boxrud, Albert Rovira, Alison E. Mather, Andres Perez, and Julio Alvarez
Author affiliations: Hebrew University of Jerusalem, Jerusalem, Israel (E. Elnekave); University of Minnesota, St. Paul, Minnesota, USA (E. Elnekave, S. Lim, A. Rovira, A. Perez, J. Alvarez); University of Leuven, Leuven, Belgium (S.L. Hong); Minnesota Department of Health, St. Paul (D. Boxrud); Quadram Institute Bioscience, Norwich, UK (A.E. Mather); University of East Anglia, Norwich (A.E. Mather); Universidad Complutense, Madrid, Spain (J. Alvarez)

Main Article

Table

Association between collection location and presence of resistance genetic determinants in sequences of Salmonella enterica subspecies enterica serotype 4,[5],12:i:- sequence type 34 isolates collected in Europe and the United States, 2008–2017*

Conferring resistance to Presence of genetic resistance determinants No. positives/total (%)
 Odds ratio (95% CI), United States vs. Europe p value†
Europe United States
ASSuT
 ASSuT‡
 406/690 (58.84)
 572/741 (77.19)
 2.37 (1.87–3.00)
 <0.001
Extended-spectrum cephalosporins
 blaCTX-M genes§ 4/690 (0.58) 14/741 (1.89) 3.30 (1.03–13.84) 0.032
blaCMY-2 2/690 (0.29) 37/741 (4.99) 18.06 (4.63–155.09) <0.001
blaSHV-12
 0/690¶
 27/741 (3.64)
 53.15 (3.24–873.11)
 <0.001
Quinolones qnrB19 9/690 (1.3) 51/741 (6.88) 5.59 (2.70–13.01) <0.001
qnrB2 0/690¶ 20/741 (2.7) 39.24 (2.36–650.05) <0.001
qnrS1 6/690 (0.87) 13/741 (1.75) 2.03 (0.72–6.57) 0.22
aac(6¢)-Ib-cr 1/690 (0.14) 19/741 (2.56) 18.11 (2.86–751.91) <0.001

*ASSuT indicates ampicillin, streptomycin, sulfonamides, and tetracycline.
†A statistically significant p value (boldface) is <0.05/8 = 0.00625 (adjusted for multiple comparisons using Bonferroni’s correction).
‡Simultaneous presence of blaTEM-1, strA, strB, sul2, and tet(B) genes (Appendix 2).
§Including blaCTX-M-1 (n = 1), blaCTX-M-14 (n = 2), blaCTX-M-55 (n = 14), and blaCTX-M-65 (n = 1).
¶Haldane-Anscombe correction (adding 0.5 to all 4 cells) was used to account for cells with a value of 0.

Main Article

Page created: September 30, 2020
Page updated: November 19, 2020
Page reviewed: November 19, 2020
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