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Volume 26, Number 12—December 2020
Dispatch

Transmission of Multidrug-Resistant Salmonella enterica Subspecies enterica 4,[5],12:i:- Sequence Type 34 between Europe and the United States

Ehud ElnekaveComments to Author , Samuel L. Hong, Seunghyun Lim, Dave Boxrud, Albert Rovira, Alison E. Mather, Andres Perez, and Julio Alvarez
Author affiliations: Hebrew University of Jerusalem, Jerusalem, Israel (E. Elnekave); University of Minnesota, St. Paul, Minnesota, USA (E. Elnekave, S. Lim, A. Rovira, A. Perez, J. Alvarez); University of Leuven, Leuven, Belgium (S.L. Hong); Minnesota Department of Health, St. Paul (D. Boxrud); Quadram Institute Bioscience, Norwich, UK (A.E. Mather); University of East Anglia, Norwich (A.E. Mather); Universidad Complutense, Madrid, Spain (J. Alvarez)

Main Article

Table

Association between collection location and presence of resistance genetic determinants in sequences of Salmonella enterica subspecies enterica serotype 4,[5],12:i:- sequence type 34 isolates collected in Europe and the United States, 2008–2017*

Conferring resistance to Presence of genetic resistance determinants No. positives/total (%)
 Odds ratio (95% CI), United States vs. Europe p value†
Europe United States
ASSuT
 ASSuT‡
 406/690 (58.84)
 572/741 (77.19)
 2.37 (1.87–3.00)
 <0.001
Extended-spectrum cephalosporins
 blaCTX-M genes§ 4/690 (0.58) 14/741 (1.89) 3.30 (1.03–13.84) 0.032
blaCMY-2 2/690 (0.29) 37/741 (4.99) 18.06 (4.63–155.09) <0.001
blaSHV-12
 0/690¶
 27/741 (3.64)
 53.15 (3.24–873.11)
 <0.001
Quinolones qnrB19 9/690 (1.3) 51/741 (6.88) 5.59 (2.70–13.01) <0.001
qnrB2 0/690¶ 20/741 (2.7) 39.24 (2.36–650.05) <0.001
qnrS1 6/690 (0.87) 13/741 (1.75) 2.03 (0.72–6.57) 0.22
aac(6¢)-Ib-cr 1/690 (0.14) 19/741 (2.56) 18.11 (2.86–751.91) <0.001

*ASSuT indicates ampicillin, streptomycin, sulfonamides, and tetracycline.
†A statistically significant p value (boldface) is <0.05/8 = 0.00625 (adjusted for multiple comparisons using Bonferroni’s correction).
‡Simultaneous presence of blaTEM-1, strA, strB, sul2, and tet(B) genes (Appendix 2).
§Including blaCTX-M-1 (n = 1), blaCTX-M-14 (n = 2), blaCTX-M-55 (n = 14), and blaCTX-M-65 (n = 1).
¶Haldane-Anscombe correction (adding 0.5 to all 4 cells) was used to account for cells with a value of 0.

Main Article

Page created: September 30, 2020
Page updated: November 19, 2020
Page reviewed: November 19, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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