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Volume 26, Number 12—December 2020
Dispatch

Outbreaks of Highly Pathogenic Avian Influenza (H5N6) Virus Subclade 2.3.4.4h in Swans, Xinjiang, Western China, 2020

Yanbing Li, Minghui Li, Yulei Li, Jingman Tian, Xiaoli Bai, Cen Yang, Jianzhong Shi, Ridengcaicike Ai, Weidong Chen, Wentao Zhang, Jie Li, Yufei Kong, Yuntao Guan, and Hualan ChenComments to Author 
Author affiliations: State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang, China (Y. Li, M. Li, Y. Li, J. Tian, X. Bai, J. Shi, C. Yang, Y. Kong, Y. Guan, H. Chen); Preventive and Control Center for Animal Disease of Xinjiang Uyghur Autonomous Region, Urumqi, Xinjiang Wei Autonomous Region, China (R. Ai, J. Li); Preventive and Control Center for Animal Disease of Xinjiang Crops, Urumqi (W. Zhang, J. Li)

Main Article

Table 2

Virulence related molecular markers detected in the WS/XJ/1/2020 (H5N6) virus detected among migratory whooper swans (Cygnus cygnus) and mute swans (C. olor), Xinjiang Province, China, January 2020

Protein Amino acid/motif Phenotypic consequences
Hemagglutinin
 Cleavage site motif: -RRKR¯G-
 Polybasic cleavage motif sequence required for high pathogenicity of avian influenza viruses in chickens
Neuraminidase
 Stalk deletion 58–68
 Increased virulence in mice
Polymerase acidic protein
 515T
 Increased polymerase activity in mammalian cells
Matrix protein 1
 30D Increased virulence in mice
215A
 Increased virulence in mice
Nonstructural protein 1 80–84 deletion Increased virulence in mice
42S Increased virulence in mice
98F Increased virulence in mice
101M Increased virulence in mice
222–225 ESEV (PDZ domain) Increased virulence in mice

Main Article

Page created: September 02, 2020
Page updated: November 19, 2020
Page reviewed: November 19, 2020
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