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Volume 26, Number 12—December 2020
Research

Small Particle Aerosol Exposure of African Green Monkeys to MERS-CoV as a Model for Highly Pathogenic Coronavirus Infection

Allison Totura1, Virginia Livingston, Ondraya Frick, David Dyer, Donald Nichols, and Aysegul NalcaComments to Author 
Author affiliation: Author affiliation: US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA

Main Article

Figure 4

Interstitial pneumonia observed in lung samples from African green monkeys. Hemolysin and eosin–stained lung sample sections were collected from African green monkeys exposed to aerosolized Middle East respiratory syndrome coronavirus at 28 days postinfection. Images shown reflect a sample of lung disease observed in the 103 PFU dose group (A) (original magnification × 20), 104 PFU dose group (B) (original magnification × 20), and 105 PFU dose group (C) (original magnification × 10). Samples were evaluated by a trained pathologist and scored for lesions associated with severe respiratory disease.

Figure 4. Interstitial pneumonia observed in lung samples from African green monkeys. Hemolysin and eosin–stained lung sample sections were collected from African green monkeys exposed to aerosolized Middle East respiratory syndrome coronavirus at 28 days postinfection. Images shown reflect a sample of lung disease observed in the 103 PFU dose group (A) (original magnification × 20), 104 PFU dose group (B) (original magnification × 20), and 105 PFU dose group (C) (original magnification × 10). Samples were evaluated by a trained pathologist and scored for lesions associated with severe respiratory disease.

Main Article

1Current affiliation: US Department of Health and Human Services Biomedical Advanced Research and Development Authority, Washington, DC, USA

Page created: July 22, 2020
Page updated: November 19, 2020
Page reviewed: November 19, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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