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Volume 26, Number 12—December 2020

Research

Small Particle Aerosol Exposure of African Green Monkeys to MERS-CoV as a Model for Highly Pathogenic Coronavirus Infection

Allison Totura1, Virginia Livingston, Ondraya Frick, David Dyer, Donald Nichols, and Aysegul NalcaComments to Author 
Author affiliation: Author affiliation: US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA

Main Article

Figure 1

Study schedule for small particle aerosol infection of African green monkeys (AGMs) with MERS-CoV. Three groups of AGMs (4 in each group) were exposed to 3 different target doses of MERS-CoV EMC/2012 strain by small particle aerosol exposure. AGMs were observed at indicated days postinfection (shown by squares) for metrics that would indicate recapitulation of MERS-CoV infection in humans. MERS-CoV, Middle East respiratory syndrome coronavirus.

Figure 1. Study schedule for small particle aerosol infection of African green monkeys (AGMs) with MERS-CoV. Three groups of AGMs (4 in each group) were exposed to 3 different target doses of MERS-CoV EMC/2012 strain by small particle aerosol exposure. AGMs were observed at indicated days postinfection (shown by squares) for metrics that would indicate recapitulation of MERS-CoV infection in humans. MERS-CoV, Middle East respiratory syndrome coronavirus.

Main Article

1Current affiliation: US Department of Health and Human Services Biomedical Advanced Research and Development Authority, Washington, DC, USA

Page created: July 22, 2020
Page updated: November 19, 2020
Page reviewed: November 19, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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