Volume 26, Number 12—December 2020
Research
Small Particle Aerosol Exposure of African Green Monkeys to MERS-CoV as a Model for Highly Pathogenic Coronavirus Infection
Allison Totura1, Virginia Livingston, Ondraya Frick, David Dyer, Donald Nichols, and Aysegul Nalca
Table 2
Summary of histological findings from African green monkeys exposed to MERS-CoV*
| Animal ID | Sex | Target dose, 10x PFU | Type of lung lesion | Location and severity of lung lesion |
|||
|---|---|---|---|---|---|---|---|
| Left superior | Right superior | Left inferior | Right inferior | ||||
| 1 | F | 3 | Multifocal interstitial pneumonia | Minimal | Minimal | Minimal | Minimal |
| 2 | M | 3 | Multifocal interstitial pneumonia | Minimal | Minimal | NLP | NLP |
| 3 | M | 3 | Multifocal broncho-interstitial pneumonia | Mild | Mild | Minimal | Minimal |
| 4 | F | 3 | Multifocal interstitial pneumonia | Minimal | Minimal | Minimal | Minimal |
| 5 | F | 4 | Multifocal broncho-interstitial pneumonia | Minimal | Minimal | NLP | NLP |
| 6 | M | 4 | Multifocal foreign-body bronchiolitis | NLP | NLP | Mild | Mild |
| 7 | M | 4 | Multifocal broncho-interstitial pneumonia | Minimal | Minimal | NLP | NLP |
| 8 | F | 4 | Multifocal interstitial pneumonia | Minimal | Minimal | Mild | Mild |
| 9 | F | 5 | Multifocal interstitial pneumonia | NLP | NLP | Minimal | Minimal |
| 10 | M | 5 | Multifocal interstitial pneumonia | Mild | Mild | Minimal | Minimal |
| 11 | M | 5 | Multifocal interstitial pneumonia | Minimal | Minimal | Minimal | Minimal |
| 12 | F | 5 | Multifocal interstitial fibrosis | NLP | NLP | Minimal | NLP |
*MERS-CoV, Middle East respiratory syndrome coronavirus; NLP, no lesion present.
1Current affiliation: US Department of Health and Human Services Biomedical Advanced Research and Development Authority, Washington, DC, USA
Page created: July 22, 2020
Page updated: November 19, 2020
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