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Volume 26, Number 12—December 2020
Dispatch

Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells

Susanna K.P. Lau1Comments to Author , Antonio C.P. Wong1, Hayes K.H. Luk1, Kenneth S.M. Li, Joshua Fung, Zirong He, Flora K.K. Cheng, Tony T.Y. Chan, Stella Chu, Kam Leng Aw-Yong, Terrence C.K. Lau, Kitty S.C. Fung, and Patrick C.Y. WooComments to Author 
Author affiliations: The University of Hong Kong, Hong Kong, China (S.K.P. Lau, A.C.P. Wong, H.K.K. Luk, K.S.M. Li, J. Fung, Z. He, F.K.K. Cheng, T.T.Y. Chan, S. Chu, K.L. Aw-Yong, P.C.Y. Woo); City University of Hong Kong, Hong Kong (T.C.K. Lau); United Christian Hospital, Kwun Tong, Hong Kong (K.S.C. Fung)

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Figure 1

Susceptibilities of 13 bat cell lines to infection by SARS-CoV (A) and SARS-CoV-2 (B) shown from harvest of supernatants and cell lysates at day 0 and 5 postinfection. Viral titers and β-Actin mRNA were determined by real-time quantitative reverse transcription PCR. Viral load is expressed as normalized fold change in log10. Error bars indicate SDs of triplicate samples. Bat cell lines are listed by species and organ. Vero cells served as controls. Asterisk (*) indicates p<0.05 and increase in viral load >1 log10. Mp, Miniopterus pusillus, Mr, Myotis ricketti; Pa, Pipistrellus abramus, Rl, Rousettus leschenaultii, Rs, Rhinolophus sinicus, Tp, Tylonycteris pachypus. SARS-CoV, severe acute respiratory syndrome coronavirus.

Figure 1. Susceptibilities of 13 bat cell lines to infection by SARS-CoV (A) and SARS-CoV-2 (B) shown from harvest of supernatants and cell lysates at day 0 and 5 postinfection. Viral titers and β-Actin mRNA were determined by real-time quantitative reverse transcription PCR. Viral load is expressed as normalized fold change in log10. Error bars indicate SDs of triplicate samples. Bat cell lines are listed by species and organ. Vero cells served as controls. Asterisk (*) indicates p<0.05 and increase in viral load >1 log10. Mp, Miniopterus pusillus, Mr, Myotis ricketti; Pa, Pipistrellus abramus, Rl, Rousettus leschenaultii, Rs, Rhinolophus sinicus, Tp, Tylonycteris pachypus. SARS-CoV, severe acute respiratory syndrome coronavirus.

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1These authors contributed equally to this article.

Page created: July 17, 2020
Page updated: November 19, 2020
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