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Volume 26, Number 12—December 2020

Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells

Susanna K.P. Lau1Comments to Author , Antonio C.P. Wong1, Hayes K.H. Luk1, Kenneth S.M. Li, Joshua Fung, Zirong He, Flora K.K. Cheng, Tony T.Y. Chan, Stella Chu, Kam Leng Aw-Yong, Terrence C.K. Lau, Kitty S.C. Fung, and Patrick C.Y. WooComments to Author 
Author affiliations: The University of Hong Kong, Hong Kong, China (S.K.P. Lau, A.C.P. Wong, H.K.K. Luk, K.S.M. Li, J. Fung, Z. He, F.K.K. Cheng, T.T.Y. Chan, S. Chu, K.L. Aw-Yong, P.C.Y. Woo); City University of Hong Kong, Hong Kong (T.C.K. Lau); United Christian Hospital, Kwun Tong, Hong Kong (K.S.C. Fung)

Main Article

Table 2

Viral load changes and cytopathic effects of severe acute respiratory syndrome coronavirus and coronavirus 2 in different cell lines on day 5 postinfection*

Cell lines SARS-CoV
Viral load change, log10 p value CPE Viral load change, log10 p value CPE
Rousettus leschenaultii intestine 0.63 0.0083 0.59 0.0039
Rousettus leschenaultii kidney 0.33 0.0071 0.15 0.0950
Rousettus leschenaultii brain 0.84 0.0019 0.77 0.0004
Rousettus leschenaultii lung 0.39 0.2345 −0.31 0.1224
Rhinolophus sinicus lung 0.91 0.0226 1.08 0.0002
Rhinolophus sinicus brain 1.09 0.0251 1.46 0.0022
Rhinolophus sinicus kidney 3.48 <0.0001 + 0.28 0.1280
Miniopterus pusillus kidney −0.14 0.0372 0.10 0.0241
Pipistrellus abramus kidney 1.45 0.0176 + 1.71 <0.0001 +
Pipistrellus abramus lung −0.21 0.2401 −0.09 0.4218
Tylonycteris pachypus kidney −0.27 0.0051 0.82 0.0003
Myotis ricketti kidney −0.14 0.1683 0.07 0.7615
Myotis ricketti lung −0.41 0.0289 −0.32 0.0240
Vero 7.12 <0.0001 + 3.88 <0.0001 +

*CoV, coronavirus; CPE, cytopathic effects; SARS, severe acute respiratory syndrome.

Main Article

1These authors contributed equally to this article.

Page created: July 17, 2020
Page updated: November 19, 2020
Page reviewed: November 19, 2020
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