Volume 26, Number 2—February 2020
Research
Unique Clindamycin-Resistant Clostridioides difficile Strain Related to Fluoroquinolone-Resistant Epidemic BI/RT027 Strain
Andrew M. Skinner
, Laurica Petrella, Farida Siddiqui, Susan P. Sambol, Christopher A. Gulvik, Dale N. Gerding, Curtis J. Donskey, and Stuart Johnson
, Laurica Petrella, Farida Siddiqui, Susan P. Sambol, Christopher A. Gulvik, Dale N. Gerding, Curtis J. Donskey, and Stuart Johnson
Table
Comparison of baseline characteristics and outcomes of patients colonized or infected with Clostridioides difficile DQ/591, BI/NAP1/027, and other strain types in study of C. difficile at 2 US Veteran Affairs long-term care facilities and their affiliated acute care facilities*
| Characteristic | Strain type |
||
|---|---|---|---|
| DQ/591, n = 15 | BI/027, n = 22 | Other, n = 27 | |
| Age, y (range) |
67.9 (49–85) |
68.9 (57–89) |
67.4 (48–91) |
| Sex | |||
| M | 15 (100) | 22 (100) | 26 (96) |
| F |
0 |
0 |
1 (4) |
| Residence | |||
| Long-term care facility | 10 (67) | 7 (32)† | 8 (30)† |
| Spinal cord injury unit |
4 (27) |
8 (36) |
7 (26) |
| Drugs received | |||
| Proton pump inhibitor | 12 (80) | 11 (50) | 19 (70) |
| Antimicrobial drug treatment in past 90 d | 15 (100) | 14 (64)† | 15 (56)† |
| Fluoroquinolone in past 90 d | 5 (33) | 6 (27) | 6 (22) |
| Clindamycin in past 90 d | 1 (7) | 0 | 0 |
| Azithromycin in past 90 d |
1 (7) |
0 |
0 |
| Intensive care unit admission in past 30 d |
4 (27) |
4 (18) |
0† |
| Medical conditions | |||
| Chronic lung disease | 6 (40) | 4 (18) | 5 (19) |
| Cancer | 5 (33) | 5 (23) | 5 (19) |
| Major surgery in past 90 d | 3 (20) | 1 (4.5) | 5 (19) |
| End-stage renal disease |
3 (20) |
4 (18) |
4 (15) |
| Disease classification, no. (%) | |||
| C. difficile infection | 7 (47) | 13 (59) | 16 (59) |
| Severe | 3 (43) | 3 (23) | 1 (6) |
| Fulminant | 0 | 0 | 0 |
| Recurrent | 3 (43) | 2 (15) | 4 (25) |
| Healthcare-associated | 7 (100) | 11 (85) | 8 (50)† |
| Asymptomatic carrier | 8 (53) | 9 (41) | 11 (41) |
| Died within 6 mo after CDI diagnosis | 4 (27) | 6 (27) | 1 (4)† |
*Values for BI/027 and for other strain types were compared with values for DQ/591 strains.
†p<0.05.
Page created: January 17, 2020
Page updated: January 17, 2020
Page reviewed: January 17, 2020
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