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Volume 26, Number 2—February 2020
Etymologia

Etymologia: Pegivirus

Ronnie HenryComments to Author 

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Pegivirus [pegʺi-viʹrǝs]

In 1967, researchers studying non-A, non-B hepatitis identified a transmissible agent in the serum of a surgeon (initials G.B.) with acute hepatitis and named it the GB agent. In the 1990s, researchers from Abbott Laboratories identified 3 GB viruses (A, B, and C) at the same time as a group at Genelabs isolated RNA from patients with non-A, non-B hepatitis and named it hepatitis G virus. Later research showed that GB virus C and hepatitis G virus were the same species.

Subsequent phylogenetic analysis showed that GB viruses A and C (and GB virus D, later identified in bats) should be classified under a new genus, Pegivirus (because they cause persistent infection and because of the historic association with hepatitis G), and GB virus B should be classified as a second species (with hepatitis C virus) in the genus Hepacivirus. As of 2016, 11 species of Pegivirus had been identified (Pegivirus A–K).

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References

  1. Linnen  J, Wages  J Jr, Zhang-Keck  ZY, Fry  KE, Krawczynski  KZ, Alter  H, et al. Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent. Science. 1996;271:5058. DOIPubMed
  2. Simons  JN, Leary  TP, Dawson  GJ, Pilot-Matias  TJ, Muerhoff  AS, Schlauder  GG, et al. Isolation of novel virus-like sequences associated with human hepatitis. Nat Med. 1995;1:5649. DOIPubMed
  3. Smith  DB, Becher  P, Bukh  J, Gould  EA, Meyers  G, Monath  T, et al. Proposed update to the taxonomy of the genera Hepacivirus and Pegivirus within the Flaviviridae family. J Gen Virol. 2016;97:2894907. DOIPubMed
  4. Stapleton  JT, Foung  S, Muerhoff  AS, Bukh  J, Simmonds  P. The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae. J Gen Virol. 2011;92:23346. DOIPubMed

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Cite This Article

DOI: 10.3201/eid2602.et2602

Original Publication Date: January 07, 2020

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Table of Contents – Volume 26, Number 2—February 2020

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Ronnie Henry, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop E28, Atlanta, GA 30333, USA

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Page created: January 17, 2020
Page updated: January 17, 2020
Page reviewed: January 17, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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