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Volume 26, Number 6—June 2020
Research

Endemic Chromoblastomycosis Caused Predominantly by Fonsecaea nubica, Madagascar1

Tahinamandranto Rasamoelina, Danièle Maubon, Malalaniaina Andrianarison, Irina Ranaivo, Fandresena Sendrasoa, Njary Rakotozandrindrainy, Fetra A. Rakotomalala, Sébastien Bailly, Benja Rakotonirina, Abel Andriantsimahavandy, Fahafahantsoa Rakato Rabenja, Mala R. Andrianarivelo, Muriel CornetComments to Author , and Lala S. Ramarozatovo
Author affiliations: Université d’Antananarivo, Antananarivo, Madagascar (T. Rasamoelina, N. Rakotozandrindrainy, F.A. Rakotomalala, B. Rakotonirina, A. Andriantsimahavandy, M.Rakato Andrianarivelo); Université Grenoble Alpes, Grenoble, France (D. Maubon, S. Bailly, M. Cornet); Hôpital Universitaire Joseph Raseta Befelatanana, Antananarivo (M. Andrianarison, I. Ranaivo, F. Sendrasoa, F.R. Rabenja, L.S. Ramarozatovo); Centre Hospitalier Universitaire de Befelatanana, Antananarivo (L.S. Ramarozatovo)

Main Article

Table 4

Minimal inhibitory concentrations of 5 antifungal drugs for Fonsecaea nubica) and Cladophialophora carrionii (n = 5) strains, Madagascar*

Fungi, drug MIC, μg/mL and no. isolates
 Geometric mean, μg/mL (range)
0.008 0.015 0.02 0.031 0.062 0.125 0.25 0.5 1.0 2.0
F. nubica, n = 15
ITZ 0 0 0 5 3 4 1 1 1 0 0.101 (0.031–1.0)
PSZ 0 11 0 2 2 0 0 0 0 0 0.021 (0.015–0.062)
ISZ 1 3 0 10 1 0 0 0 0 0 0.027 (0.008–0.006)
TRB 11 1 2 1 0 0 0 0 0 0 0.012 (0.008–0.003)
AMB
 0
 0
 0
 0
 1
 2
 4
 6
 1
 1
 0.692 (0.062–4.0)
C. carrionii, n = 5
ITZ 0 0 1 1 0 2 0 1 0 0 0.094 (0.031–1.0)
PSZ 0 0 2 2 0 0 1 0 0 0 0.071 (0.031–0.5)
ISZ 0 0 2 2 0 0 1 0 0 0 0.071 (0.031–0.5)
TRB 2 2 0 0 1 0 0 0 0 2 0.024 (0.008–0.125)
AMB 0 0 0 0 0 0 0 0 5 0 4.595 (2.0–8.0)

*AMB, amphotericin B; ISZ, isavuconazole; ITZ, itraconazole; PSZ, posaconazole; TRB, terbinafine.

Main Article

1Preliminary results from this study were presented at the 20th International Society for Human and Animal Mycology Conference; June 29–July 5, 2018; Amsterdam, the Netherlands.

Page created: May 18, 2020
Page updated: May 18, 2020
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