Plasma-Derived Extracellular Vesicles as Potential Biomarkers in Heart Transplant Patient with Chronic Chagas Disease
Nuria Cortes-Serra, Maria Tays Mendes, Clara Mazagatos
1, Joan Segui-Barber, Cameron C. Ellis, Cristina Ballart, Ana Garcia-Alvarez, Montserrat Gállego, Joaquim Gascon, Igor C. Almeida, María Jesús Pinazo
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, and Carmen Fernandez-Becerra
Author affiliations: Barcelona Institute for Global Health (ISGlobal), Universitat de Barcelona, Barcelona, Spain (N. Cortes-Serra, C. Mazagatos, J. Segui-Barber, C. Ballart, M. Gállego, J. Gascon, M.J. Pinazo, C. Fernandez-Becerra); Border Biomedical Research Center, The University of Texas at El Paso, El Paso, Texas USA (M.T. Mendes, C.C. Ellis, I.C. Almeida); Secció de Parasitologia, Departament de Biologia, Sanitat i Medi Ambient, Facultat de Farmàcia i Ciències de l’Alimentació, Universitat de Barcelona, Barcelona, Spain (C. Ballart, M. Gállego); Arrhythmias Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain (A. Garcia-Alvarez); Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona, Spain (C. Fernandez-Becerra)
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Figure 2
Figure 2. Human proteomic profile of plasma-derived EVs from a heart transplant patient with chronic Chagas disease before and after BZN treatment and from 2 healthy donors. Heatmap of the identified human EV-derived proteins. Heatmap was generated from proteomic data by the Scaffold perSPECtives software (Proteome Software, http://www.proteomesoftware.com). Hierarchical clustering was performed based on the normalized weighted spectrum count. Higher numbers of human proteins were found in EVs isolated from the patient, before and after benznidazole treatment, compared with EVs derived from the 2 healthy donors (H1, H2). Scale bar indicates intensity. BZN, benznidazole; EV, extracellular vesicle.
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