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Volume 26, Number 8—August 2020

Increased Sensitivity of Plasmodium falciparum to Artesunate/Amodiaquine Despite 14 Years as First-Line Malaria Treatment, Zanzibar

Mwinyi Msellem, Ulrika Morris, Aungpaing Soe, Faiza B. Abbas, Abdul-Wahid Ali, Rory Barnes, Paolo Frumento, Abdullah S. Ali, Andreas Mårtensson, and Anders BjörkmanComments to Author 
Author affiliations: Mnazi Mmoja Hospital, Zanzibar, Tanzania (M. Msellem); Karolinska Institutet, Stockholm, Sweden (U. Morris, A. Soe, R. Barnes, P. Frumento, A. Bjorkman); Zanzibar Malaria Elimination Programme, Zanzibar, Tanzania (F.B. Abbas, A.-W. Ali, A.S. Ali); Uppsala University, Uppsala, Sweden (A. Mårtensson)

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Table 1

Characteristics of patients in 3 clinical trials testing increased sensitivity of Plasmodium falciparum to artesunate/amodiaquine despite 14 years as first-line malaria treatment, Zanzibar

Characteristic Study group
2002–2003 2005 2017
No. screened* 2,097 2,076 9,062
No. enrolled 207 177 146
M:F ratio 104:103 82:95 101:45
Median age (range) 24 (5–73) mo 28 (4–60) mo 16 (2–60) y
Geometric mean parasite density per microliter (range) 19,731 (2,000–198,000) 20,890 (2,000–176,000) 7,886 (75–304,000)
Mean ± SD temperature, °C 38.7 ± 1.2 37.8 ± 1.2 37.8 ± 1.4
Mean ± SD hemoglobin level, g/dL 8.5 ± 1.6 9.2 ± 1.4 11.9 ± 2.2

*Febrile patients attending healthcare facilities with suspected uncomplicated P. falciparum malaria infections.

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Page created: May 26, 2020
Page updated: July 17, 2020
Page reviewed: July 17, 2020
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