Volume 26, Number 8—August 2020
Research
Increased Sensitivity of Plasmodium falciparum to Artesunate/Amodiaquine Despite 14 Years as First-Line Malaria Treatment, Zanzibar
Mwinyi Msellem, Ulrika Morris, Aungpaing Soe, Faiza B. Abbas, Abdul-Wahid Ali, Rory Barnes, Paolo Frumento, Abdullah S. Ali, Andreas Mårtensson, and Anders Björkman
Table 6
Association between PCR positivity on days 3, 7, and 28 after treatment and patient characteristics at study baseline, Zanzibar*
| Characteristic | PCR negative, day 3 | PCR positive, day 3 | p value,† day 3 | PCR negative, day 7 | PCR positive, day 7 | p value,† day 7 | PCR negative, day 28 | PCR positive, day 28 | p value,† day 28 |
|---|---|---|---|---|---|---|---|---|---|
| Total (%) |
52/142 (37) |
90/142 (63) |
NA |
100/142 (70) |
42/142 (30) |
NA |
133/142 (94) |
9/142 (6) |
|
| M:F ratio |
33:19 |
65:25 |
0.35 |
70:30 |
28:14 |
0.70 |
91:42 |
72 |
0.72 |
| Median age, y (range) |
24 (2–57) |
14 (2–60) |
<0.001 |
19 (2–60) |
12.5 (2–54) |
0.01 |
17 (2–60) |
14 (9–56) |
0.54 |
| Geometric mean parasite density/µL (range) |
3,998
(75–120,955) |
12,011
(78–304,269) |
<0.001 |
6,185
(76–145,750) |
14,940 (561–304,269) |
0.01 |
7,847
(78–304,269) |
11,259 (2,730–56,304) |
0.61 |
| Mean ± SD temperature, °C |
37.2 ± 1.2 |
38.1 ± 1.3 |
<0.001 |
37.7 ± 1.4 |
38.0 ± 1.2 |
0.27 |
37.8 ± 1.4 |
38.0 ± 1.2 |
0.62 |
| Mean ± SD hemoglobin level, g/dL | 12.4 ± 2.2 | 11.7 ± 2.2 | 0.09 | 12.2 ± 2.2 | 11.3 ± 2.2 | 0.01 | 12.0 ± 2.3 | 11.4 ± 1.5 | 0.37 |
*NA, not applicable.
†Calculated by Fisher exact test (for sex) or Wilcoxon rank-sum (Mann-Whitney) test for continuous variables.
Page created: May 26, 2020
Page updated: July 17, 2020
Page reviewed: July 17, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.